Sequence sensitivity of breathing dynamics in heteropolymer DNA

Tobias Ambjörnsson, Suman K. Banik, Oleg Krichevsky, Ralf Metzler

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

We study the fluctuation dynamics of localized denaturation bubbles in heteropolymer DNA with a master equation and complementary stochastic simulation based on novel DNA stability data. A significant dependence of opening probability and waiting time between bubble events on the local DNA sequence is revealed and quantified for a biological sequence of the T7 bacteriophage. Quantitative agreement with data from fluorescence correlation spectroscopy is demonstrated.

Original languageEnglish
Article number128105
JournalPhysical Review Letters
Volume97
Issue number12
DOIs
StatePublished - 29 Sep 2006

ASJC Scopus subject areas

  • Physics and Astronomy (all)

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