Abstract
We study the fluctuation dynamics of localized denaturation bubbles in heteropolymer DNA with a master equation and complementary stochastic simulation based on novel DNA stability data. A significant dependence of opening probability and waiting time between bubble events on the local DNA sequence is revealed and quantified for a biological sequence of the T7 bacteriophage. Quantitative agreement with data from fluorescence correlation spectroscopy is demonstrated.
Original language | English |
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Article number | 128105 |
Journal | Physical Review Letters |
Volume | 97 |
Issue number | 12 |
DOIs | |
State | Published - 29 Sep 2006 |
ASJC Scopus subject areas
- General Physics and Astronomy