Serotype replacement in perspective

Ron Dagan

doi:10.1016/j.vaccine.2009.06.004

Serotype replacement in perspective

Ron Dagan

The Shraga Segal Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

An increase in the incidence of invasive pneumococcal disease (IPD) caused by non-vaccine serotypes (NVTs) (serotype replacement) has been observed since the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7), primarily in the elderly, HIV-positive adults, and children with underlying medical conditions. In children aged <5 years, only a slight increase in replacement disease due to NVTs has been observed, but the relationship of changes in serotype carriage to replacement disease is not well understood. Predominant post-PCV7 NVTs include serotypes 15, 19A, and 33F, but the increasing antibiotic resistance of 19A is of particular concern in both vaccinated and unvaccinated populations.

Original language	English
Pages (from-to)	C22-C24
Journal	Vaccine
Volume	27
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/j.vaccine.2009.06.004
State	Published - 21 Aug 2009

Keywords

Pneumococcal serotypes
Replacement disease
Serotype 19A

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2009.06.004

Cite this

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AB - An increase in the incidence of invasive pneumococcal disease (IPD) caused by non-vaccine serotypes (NVTs) (serotype replacement) has been observed since the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7), primarily in the elderly, HIV-positive adults, and children with underlying medical conditions. In children aged <5 years, only a slight increase in replacement disease due to NVTs has been observed, but the relationship of changes in serotype carriage to replacement disease is not well understood. Predominant post-PCV7 NVTs include serotypes 15, 19A, and 33F, but the increasing antibiotic resistance of 19A is of particular concern in both vaccinated and unvaccinated populations.

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ER -

Serotype replacement in perspective

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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