Serum and CSF levels of haloperidol by radioimmunoassay and radioreceptor assay during high-dose therapy of resistant schizophrenic patients

Ranan Rimón; Ilya Averbuch; Pablo Rozick; L. Fijman-Danilovich; Thomas Kara; Haim Dasberg; Richard P. Ebstein; Robert H. Belmaker

doi:10.1007/BF00429218

Serum and CSF levels of haloperidol by radioimmunoassay and radioreceptor assay during high-dose therapy of resistant schizophrenic patients

Ranan Rimón, Ilya Averbuch, Pablo Rozick, L. Fijman-Danilovich, Thomas Kara, Haim Dasberg, Richard P. Ebstein, Robert H. Belmaker

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Serum and cerebrospinal fluid (CSF) levels of haloperidol were measured in 12 chronic neuroleptic-non-responsive schizophrenic patients after 1 month on 60 mg haloperidol daily and then again after 1 month on 120 mg haloperidol daily. Serum haloperidol and CSF haloperidol rose with increasing dose. Serum and CSF levels were significantly correlated. No clinical improvement was achieved despite the high serum and CSF drug levels.

Original language	English
Pages (from-to)	197-199
Number of pages	3
Journal	Psychopharmacology
Volume	73
Issue number	2
DOIs	https://doi.org/10.1007/BF00429218
State	Published - 1 Apr 1981
Externally published	Yes

Keywords

Blood levels
CSF
Haloperidol
Pharmacokinetics

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00429218

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title = "Serum and CSF levels of haloperidol by radioimmunoassay and radioreceptor assay during high-dose therapy of resistant schizophrenic patients",

abstract = "Serum and cerebrospinal fluid (CSF) levels of haloperidol were measured in 12 chronic neuroleptic-non-responsive schizophrenic patients after 1 month on 60 mg haloperidol daily and then again after 1 month on 120 mg haloperidol daily. Serum haloperidol and CSF haloperidol rose with increasing dose. Serum and CSF levels were significantly correlated. No clinical improvement was achieved despite the high serum and CSF drug levels.",

keywords = "Blood levels, CSF, Haloperidol, Pharmacokinetics",

author = "Ranan Rim{\'o}n and Ilya Averbuch and Pablo Rozick and L. Fijman-Danilovich and Thomas Kara and Haim Dasberg and Ebstein, {Richard P.} and Belmaker, {Robert H.}",

year = "1981",

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doi = "10.1007/BF00429218",

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pages = "197--199",

journal = "Psychopharmacology",

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T1 - Serum and CSF levels of haloperidol by radioimmunoassay and radioreceptor assay during high-dose therapy of resistant schizophrenic patients

AU - Rimón, Ranan

AU - Averbuch, Ilya

AU - Rozick, Pablo

AU - Fijman-Danilovich, L.

AU - Kara, Thomas

AU - Dasberg, Haim

AU - Ebstein, Richard P.

AU - Belmaker, Robert H.

PY - 1981/4/1

Y1 - 1981/4/1

N2 - Serum and cerebrospinal fluid (CSF) levels of haloperidol were measured in 12 chronic neuroleptic-non-responsive schizophrenic patients after 1 month on 60 mg haloperidol daily and then again after 1 month on 120 mg haloperidol daily. Serum haloperidol and CSF haloperidol rose with increasing dose. Serum and CSF levels were significantly correlated. No clinical improvement was achieved despite the high serum and CSF drug levels.

AB - Serum and cerebrospinal fluid (CSF) levels of haloperidol were measured in 12 chronic neuroleptic-non-responsive schizophrenic patients after 1 month on 60 mg haloperidol daily and then again after 1 month on 120 mg haloperidol daily. Serum haloperidol and CSF haloperidol rose with increasing dose. Serum and CSF levels were significantly correlated. No clinical improvement was achieved despite the high serum and CSF drug levels.

KW - Blood levels

KW - CSF

KW - Haloperidol

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=0019448568&partnerID=8YFLogxK

U2 - 10.1007/BF00429218

DO - 10.1007/BF00429218

M3 - Article

AN - SCOPUS:0019448568

SN - 0033-3158

VL - 73

SP - 197

EP - 199

JO - Psychopharmacology

JF - Psychopharmacology

IS - 2

ER -

Serum and CSF levels of haloperidol by radioimmunoassay and radioreceptor assay during high-dose therapy of resistant schizophrenic patients

Abstract

Keywords

ASJC Scopus subject areas

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