Serum and synovial fluid levels of serum amyloid A protein and C-reactive protein in inflammatory and noninflammatory arthritis

S. Sukenik, J. Henkin, S. Zimlichen, A. Skibin, L. Neuman, M. Pras, J. Horowitz, R. Shainkin-Kestenbaum

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Serum and synovial fluid (SF) levels of serum amyloid A (SAA) and C-reactive protein (CRP) were measured in 46 cases of various inflammatory arthritis (Group 1), and in 40 cases of noninflammatory arthritis: 18 cases of osteoarthritis (Group 2) and 22 cases of traumatic arthritis (Group 3). Serum and SF SAA levels were markedly elevated in Group 1: 126.4 μg/ml ± 19.2 SEM and 46.4 μg/ml ± 10.5 SEM, respectively; moderately elevated in Group 2: 10.1 μg/ml ± 2.9 SEM, 4.0 μg/ml ± 1.1 SEM and moderately elevated in Group 3: 10.4 μg/ml ± 1.2 SEM, 4.0 μg/ml ± 1.2 SEM, respectively. Serum/SF SAA ratios were similar in all 3 groups and ranged between 2.52-2.72. In comparison to SAA, the increment of serum and SF CRP above normal levels was moderate. A positive strong correlation was found between serum SAA and serum CRP: r = 0.64 (p<0.001) and between SF SAA and SF CRP: r = 0.59 (p<0.0001). SF SAA did not correlate with the number of SF white blood cells but did correlate with the percent of SF polymorphonuclear cells: r = 0.23 (p<0.05)

Original languageEnglish
Pages (from-to)942-945
Number of pages4
JournalJournal of Rheumatology
Volume15
Issue number6
StatePublished - 1 Jan 1988

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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