TY - JOUR
T1 - Serum creatine phosphokinase (CPK) activity in monozygotic twins discordant for schizophrenia
T2 - Heritability of serum CPK activity
AU - Meltzer, Herbert Y.
AU - Belmaker, Robert
AU - Wyatt, Richard J.
AU - Pollin, William
AU - Cohen, Steven
N1 - Funding Information:
From the Department of Psvchiatrv, Universit), of Chicago Prit:ker School of Medicine and the Illinois State Psychiatric Institute, Chicago, Ill.; the Adult P.svchiatrv Branch, National Institute o/ Mental Health, Bethesda, Md.; and the Laborator_v of Clinical P.s.vchopharmaco1og.v. National In-.stitute oJ‘Mental Health. St. Elizabeth’s Hospital, Washington. D.C. Herbert Y. Meltzer. M.D.: Professor, Department of Psychiatry. University of Chicago Prit:ker School of Medicine and the Illinois State Psvchiatric Institute: Robert Belmaker. M.D.: Clinical .4ssociate, Section on Twin and Sibling Studies, Adult Psvchiatr!, Branch, National Institute ol Mental Health: Richard J. Wyatt, M.D.: Chief: Laboratory oJ Clinical Psvchopharmacologv. National Institute of Mental Health, St. Elizabeth’s Hospital; William Pollin, M.D.: Chief. Section on Twin and Sibling Studies, Adult Psychiatry Branch, National Institute of Mental Health; Steven Cohen. M.D.: Clinical .4ssociate, Section on Twin and Sibling Studies, Adult P.yychiatry Branch, ,Ya-tional Institute qf Mental Health. Supported in part by USPHS MH Grant 16. l-77 and Grant 231-12 R. D. from the State of Illinoi.~ Department of Mental Health. Dr. Meltzer is a recipient OJ C’SPHS Career Development Award K@-MH 47,808. Keprint requests should be addressed to H. Z’. Meltzer. M.D., Department oJ’ P.svchiatrv. L’niversiiv oJ’Chicago Pritzker School oJ‘Medicine. 950 E. 59th Street, Chicago. Ill. 60649. c 1976 bv Grune & Stratton. Inc.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - Recent studies with normal monozygotic and dizygotic twins have established that serum creatine phosphokinase (CPK) activity in man is under genetic control (Meltzer, Dorus, and Davis, in preparation). This is of interest because of the reports that serum CPK activity is increased in many acutely psychotic patients, provided that they are studied in the first days after the onset of gross psychotic symptoms and throughout hospitalization.1-12 The increases range from slightly above the 95% upper limits of normal to 50-75 times the limits for each race-sex group. Furthermore, 25%-30% of the first degree relatives of psychotic patients have slight but persistent increases in serum CPK activity.2,3,7 These increases occur significantly more frequently in relatives of psychotic patients who have themselves had increases in serum CPK activity (Meltzer and Moretti, in preparation). Prior to the studies with normal twins which established that serum CPK activity is under some genetic control, we had the opportunity to study serum CPK activity in twins discordant for schizophrenia. These results will be reported here.
AB - Recent studies with normal monozygotic and dizygotic twins have established that serum creatine phosphokinase (CPK) activity in man is under genetic control (Meltzer, Dorus, and Davis, in preparation). This is of interest because of the reports that serum CPK activity is increased in many acutely psychotic patients, provided that they are studied in the first days after the onset of gross psychotic symptoms and throughout hospitalization.1-12 The increases range from slightly above the 95% upper limits of normal to 50-75 times the limits for each race-sex group. Furthermore, 25%-30% of the first degree relatives of psychotic patients have slight but persistent increases in serum CPK activity.2,3,7 These increases occur significantly more frequently in relatives of psychotic patients who have themselves had increases in serum CPK activity (Meltzer and Moretti, in preparation). Prior to the studies with normal twins which established that serum CPK activity is under some genetic control, we had the opportunity to study serum CPK activity in twins discordant for schizophrenia. These results will be reported here.
UR - http://www.scopus.com/inward/record.url?scp=84886632781&partnerID=8YFLogxK
U2 - 10.1016/0010-440X(76)90051-1
DO - 10.1016/0010-440X(76)90051-1
M3 - Article
AN - SCOPUS:84886632781
SN - 0010-440X
VL - 17
SP - 469
EP - 475
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
IS - 3
ER -