Serum cytokine levels in active uveitis and remission

M. Kramer; Y. Monselise; I. Bahar; Y. Cohen; D. Weinberger; N. Goldenberg-Cohen

doi:10.1080/02713680701523147

Serum cytokine levels in active uveitis and remission

M. Kramer, Y. Monselise, I. Bahar, Y. Cohen, D. Weinberger, N. Goldenberg-Cohen

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Serum levels of interleukin(IL)-8, IL-6, and (TNF)-α were measured in 25 patients during active uveitis and uveitis in remission and compared to age-matched controls. Levels of IL-8 and IL-6 were significantly elevated in patients with active disease and were decreased during remission. IL-8 levels were highest in patients with anterior uveitis, with greatest difference between active disease and remission. No consistent pattern was observed for TNF-α. In conclusion, serum cytokine levels are elevated in active noninfectious uveitis. The rise in IL-8 may suggest innate immune mechanisms in the acute disease, while IL-6 participates in modulation of inflammation in the chronic disease.

Original language	English
Pages (from-to)	669-675
Number of pages	7
Journal	Current Eye Research
Volume	32
Issue number	7-8
DOIs	https://doi.org/10.1080/02713680701523147
State	Published - 1 Jul 2007
Externally published	Yes

Keywords

Cytokines
IL-6
IL-8
TNF-α
Uveitis

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1080/02713680701523147

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title = "Serum cytokine levels in active uveitis and remission",

abstract = "Serum levels of interleukin(IL)-8, IL-6, and (TNF)-α were measured in 25 patients during active uveitis and uveitis in remission and compared to age-matched controls. Levels of IL-8 and IL-6 were significantly elevated in patients with active disease and were decreased during remission. IL-8 levels were highest in patients with anterior uveitis, with greatest difference between active disease and remission. No consistent pattern was observed for TNF-α. In conclusion, serum cytokine levels are elevated in active noninfectious uveitis. The rise in IL-8 may suggest innate immune mechanisms in the acute disease, while IL-6 participates in modulation of inflammation in the chronic disease.",

keywords = "Cytokines, IL-6, IL-8, TNF-α, Uveitis",

author = "M. Kramer and Y. Monselise and I. Bahar and Y. Cohen and D. Weinberger and N. Goldenberg-Cohen",

note = "Funding Information: This study was partly supported by the Fund for Young Investigator (NGC), Rabin Medical Center.",

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T1 - Serum cytokine levels in active uveitis and remission

AU - Kramer, M.

AU - Monselise, Y.

AU - Bahar, I.

AU - Cohen, Y.

AU - Weinberger, D.

AU - Goldenberg-Cohen, N.

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PY - 2007/7/1

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N2 - Serum levels of interleukin(IL)-8, IL-6, and (TNF)-α were measured in 25 patients during active uveitis and uveitis in remission and compared to age-matched controls. Levels of IL-8 and IL-6 were significantly elevated in patients with active disease and were decreased during remission. IL-8 levels were highest in patients with anterior uveitis, with greatest difference between active disease and remission. No consistent pattern was observed for TNF-α. In conclusion, serum cytokine levels are elevated in active noninfectious uveitis. The rise in IL-8 may suggest innate immune mechanisms in the acute disease, while IL-6 participates in modulation of inflammation in the chronic disease.

AB - Serum levels of interleukin(IL)-8, IL-6, and (TNF)-α were measured in 25 patients during active uveitis and uveitis in remission and compared to age-matched controls. Levels of IL-8 and IL-6 were significantly elevated in patients with active disease and were decreased during remission. IL-8 levels were highest in patients with anterior uveitis, with greatest difference between active disease and remission. No consistent pattern was observed for TNF-α. In conclusion, serum cytokine levels are elevated in active noninfectious uveitis. The rise in IL-8 may suggest innate immune mechanisms in the acute disease, while IL-6 participates in modulation of inflammation in the chronic disease.

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Serum cytokine levels in active uveitis and remission

Abstract

Keywords

ASJC Scopus subject areas

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