Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease

Moti Haim, David Tanne, Uri Goldbourt, Ram Doolman, Valentina Boyko, Daniel Brunner, Ben Ami Sela, Solomon Behar

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 μmol/l increment was associated with a 25% higher risk.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalCardiology
Volume107
Issue number1
DOIs
StatePublished - 1 Dec 2006
Externally publishedYes

Keywords

  • Homocysteine
  • Myocardial infarction
  • Risk factors

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