Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease

Moti Haim; David Tanne; Uri Goldbourt; Ram Doolman; Valentina Boyko; Daniel Brunner; Ben Ami Sela; Solomon Behar

doi:10.1159/000093697

Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease

Moti Haim
, David Tanne
, Uri Goldbourt
, Ram Doolman
, Valentina Boyko
, Daniel Brunner
, Ben Ami Sela
, Solomon Behar

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 μmol/l increment was associated with a 25% higher risk.

Original language	English
Pages (from-to)	52-56
Number of pages	5
Journal	Cardiology
Volume	107
Issue number	1
DOIs	https://doi.org/10.1159/000093697
State	Published - 1 Dec 2006
Externally published	Yes

Keywords

Homocysteine
Myocardial infarction
Risk factors

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000093697

Cite this

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title = "Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease",

abstract = "We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 μmol/l increment was associated with a 25\% higher risk.",

keywords = "Homocysteine, Myocardial infarction, Risk factors",

author = "Moti Haim and David Tanne and Uri Goldbourt and Ram Doolman and Valentina Boyko and Daniel Brunner and Sela, \{Ben Ami\} and Solomon Behar",

year = "2006",

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T1 - Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease

AU - Haim, Moti

AU - Tanne, David

AU - Goldbourt, Uri

AU - Doolman, Ram

AU - Boyko, Valentina

AU - Brunner, Daniel

AU - Sela, Ben Ami

AU - Behar, Solomon

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 μmol/l increment was associated with a 25% higher risk.

AB - We have prospectively evaluated the risk of incident coronary events in association with serum total homocysteine in patients with preexisting chronic coronary heart disease. A nested case-control design was used. Total homocysteine concentration was measured in baseline fasting serum samples from patients with chronic coronary heart disease enrolled in the Bezafibrate Infarction Prevention Study (n = 3,090) who developed coronary events during 6.2 years of follow-up (n = 69). They were matched for age and gender with controls without subsequent cardiovascular events. Elevated homocysteine levels were associated with 2.5 times higher risk of subsequent coronary events and each 5 μmol/l increment was associated with a 25% higher risk.

KW - Homocysteine

KW - Myocardial infarction

KW - Risk factors

UR - https://www.scopus.com/pages/publications/33750993264

U2 - 10.1159/000093697

DO - 10.1159/000093697

M3 - Article

C2 - 16763372

AN - SCOPUS:33750993264

SN - 0008-6312

VL - 107

SP - 52

EP - 56

JO - Cardiology

JF - Cardiology

IS - 1

ER -

Serum homocysteine and long-term risk of myocardial infarction and sudden death in patients with coronary heart disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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