Serum insulin-like growth factors I and II are not affected by undernutrition in children with nonorganic failure to thrive

Moshe Phillip; Eli Hershkovitz; Hector Rosenblum; Inbal Savion; Yael Segev; Jacob Levy; Drora Frazer

doi:10.1159/000023130

Serum insulin-like growth factors I and II are not affected by undernutrition in children with nonorganic failure to thrive

Moshe Phillip, Eli Hershkovitz, Hector Rosenblum, Inbal Savion, Yael Segev, Jacob Levy, Drora Frazer

The Shraga Segal Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The aim of our study was to determine the serum levels of IGF-I, IGF-II, and their binding proteins IGFBP-1 and IGFBP-3 in young children 3 months to 2 years of age with nonorganic failure to thrive (NOFTT). 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters. The NOFTT group had significantly higher serum concentrations of IGFBP-1 than the control group: 57.7 ± 18 vs. 48 ± 19 μg/l (p < 0.05). IGF-I and IGF-II serum levels were highly correlated to serum IGFBP-3 but there were no differences in the serum IGF-I, IGF-II and IGFBP-3 levels between the groups. We conclude that IGF-I, IGF-II, and IGFBP-3 are not useful for the evaluation of nutritional status in children, under the age of 2 years, with NOFTT.

Original language	English
Pages (from-to)	76-79
Number of pages	4
Journal	Hormone Research
Volume	49
Issue number	2
DOIs	https://doi.org/10.1159/000023130
State	Published - 1 Feb 1998

Keywords

Infant
Insulin-like growth factor binding proteins 1 and 3
Insulin-like growth factors I and II
Nonorganic failure to thrive

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1159/000023130

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title = "Serum insulin-like growth factors I and II are not affected by undernutrition in children with nonorganic failure to thrive",

abstract = "The aim of our study was to determine the serum levels of IGF-I, IGF-II, and their binding proteins IGFBP-1 and IGFBP-3 in young children 3 months to 2 years of age with nonorganic failure to thrive (NOFTT). 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters. The NOFTT group had significantly higher serum concentrations of IGFBP-1 than the control group: 57.7 ± 18 vs. 48 ± 19 μg/l (p < 0.05). IGF-I and IGF-II serum levels were highly correlated to serum IGFBP-3 but there were no differences in the serum IGF-I, IGF-II and IGFBP-3 levels between the groups. We conclude that IGF-I, IGF-II, and IGFBP-3 are not useful for the evaluation of nutritional status in children, under the age of 2 years, with NOFTT.",

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author = "Moshe Phillip and Eli Hershkovitz and Hector Rosenblum and Inbal Savion and Yael Segev and Jacob Levy and Drora Frazer",

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T1 - Serum insulin-like growth factors I and II are not affected by undernutrition in children with nonorganic failure to thrive

AU - Phillip, Moshe

AU - Hershkovitz, Eli

AU - Rosenblum, Hector

AU - Savion, Inbal

AU - Segev, Yael

AU - Levy, Jacob

AU - Frazer, Drora

PY - 1998/2/1

Y1 - 1998/2/1

N2 - The aim of our study was to determine the serum levels of IGF-I, IGF-II, and their binding proteins IGFBP-1 and IGFBP-3 in young children 3 months to 2 years of age with nonorganic failure to thrive (NOFTT). 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters. The NOFTT group had significantly higher serum concentrations of IGFBP-1 than the control group: 57.7 ± 18 vs. 48 ± 19 μg/l (p < 0.05). IGF-I and IGF-II serum levels were highly correlated to serum IGFBP-3 but there were no differences in the serum IGF-I, IGF-II and IGFBP-3 levels between the groups. We conclude that IGF-I, IGF-II, and IGFBP-3 are not useful for the evaluation of nutritional status in children, under the age of 2 years, with NOFTT.

AB - The aim of our study was to determine the serum levels of IGF-I, IGF-II, and their binding proteins IGFBP-1 and IGFBP-3 in young children 3 months to 2 years of age with nonorganic failure to thrive (NOFTT). 29 children with NOFTT and 32 normal controls were recruited and studied for auxologic and hormonal parameters. The NOFTT group had significantly higher serum concentrations of IGFBP-1 than the control group: 57.7 ± 18 vs. 48 ± 19 μg/l (p < 0.05). IGF-I and IGF-II serum levels were highly correlated to serum IGFBP-3 but there were no differences in the serum IGF-I, IGF-II and IGFBP-3 levels between the groups. We conclude that IGF-I, IGF-II, and IGFBP-3 are not useful for the evaluation of nutritional status in children, under the age of 2 years, with NOFTT.

KW - Infant

KW - Insulin-like growth factor binding proteins 1 and 3

KW - Insulin-like growth factors I and II

KW - Nonorganic failure to thrive

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JF - Hormone Research

IS - 2

ER -

Serum insulin-like growth factors I and II are not affected by undernutrition in children with nonorganic failure to thrive

Abstract

Keywords

ASJC Scopus subject areas

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