Serum prolactin in coeliac disease: A marker for disease activity

Ram Reifen, Dan Buskila, Moshe Maislos, Joseph Press, Aaron Lerner

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    21 Scopus citations


    Prolactin, a polypeptide hormone of anterior pituitary origin, has pronounced physiological effects on growth, reproduction, and osmoregulation. Increasing evidence indicates that prolactin also has an immunomodulatory influence on the immune system. The status of prolactin in patients with coellac disease was investigated by obtaining serum samples from 48 patients with active and non-active coeliac disease. These were compared with samples from 20 children with familial Mediterranean fever and 65 normal controls. Serum prolactin in patients with active coeliac disease was significantly higher than in the other groups studied and reference values. Serum prolactin correlated well with the degree of mucosal atrophy and with the serum concentration of antiendomysial antibodies. Prolactin may play a part in immune modulation in the intestinal damage of coeliac disease and serve as a potential marker for disease activity.

    Original languageEnglish
    Pages (from-to)155-157
    Number of pages3
    JournalArchives of Disease in Childhood
    Issue number2
    StatePublished - 1 Jan 1997


    • Coeliac disease
    • Prolactin


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