Serum prolactin in coeliac disease: A marker for disease activity

Ram Reifen; Dan Buskila; Moshe Maislos; Joseph Press; Aaron Lerner

doi:10.1136/adc.77.2.155

Serum prolactin in coeliac disease: A marker for disease activity

Ram Reifen, Dan Buskila, Moshe Maislos, Joseph Press, Aaron Lerner

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Prolactin, a polypeptide hormone of anterior pituitary origin, has pronounced physiological effects on growth, reproduction, and osmoregulation. Increasing evidence indicates that prolactin also has an immunomodulatory influence on the immune system. The status of prolactin in patients with coellac disease was investigated by obtaining serum samples from 48 patients with active and non-active coeliac disease. These were compared with samples from 20 children with familial Mediterranean fever and 65 normal controls. Serum prolactin in patients with active coeliac disease was significantly higher than in the other groups studied and reference values. Serum prolactin correlated well with the degree of mucosal atrophy and with the serum concentration of antiendomysial antibodies. Prolactin may play a part in immune modulation in the intestinal damage of coeliac disease and serve as a potential marker for disease activity.

Original language	English
Pages (from-to)	155-157
Number of pages	3
Journal	Archives of Disease in Childhood
Volume	77
Issue number	2
DOIs	https://doi.org/10.1136/adc.77.2.155
State	Published - 1 Jan 1997

Keywords

Coeliac disease
Prolactin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1136/adc.77.2.155

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abstract = "Prolactin, a polypeptide hormone of anterior pituitary origin, has pronounced physiological effects on growth, reproduction, and osmoregulation. Increasing evidence indicates that prolactin also has an immunomodulatory influence on the immune system. The status of prolactin in patients with coellac disease was investigated by obtaining serum samples from 48 patients with active and non-active coeliac disease. These were compared with samples from 20 children with familial Mediterranean fever and 65 normal controls. Serum prolactin in patients with active coeliac disease was significantly higher than in the other groups studied and reference values. Serum prolactin correlated well with the degree of mucosal atrophy and with the serum concentration of antiendomysial antibodies. Prolactin may play a part in immune modulation in the intestinal damage of coeliac disease and serve as a potential marker for disease activity.",

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T1 - Serum prolactin in coeliac disease

T2 - A marker for disease activity

AU - Reifen, Ram

AU - Buskila, Dan

AU - Maislos, Moshe

AU - Press, Joseph

AU - Lerner, Aaron

PY - 1997/1/1

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AB - Prolactin, a polypeptide hormone of anterior pituitary origin, has pronounced physiological effects on growth, reproduction, and osmoregulation. Increasing evidence indicates that prolactin also has an immunomodulatory influence on the immune system. The status of prolactin in patients with coellac disease was investigated by obtaining serum samples from 48 patients with active and non-active coeliac disease. These were compared with samples from 20 children with familial Mediterranean fever and 65 normal controls. Serum prolactin in patients with active coeliac disease was significantly higher than in the other groups studied and reference values. Serum prolactin correlated well with the degree of mucosal atrophy and with the serum concentration of antiendomysial antibodies. Prolactin may play a part in immune modulation in the intestinal damage of coeliac disease and serve as a potential marker for disease activity.

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Serum prolactin in coeliac disease: A marker for disease activity

Abstract

Keywords

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