Serum retinol-binding protein-4 levels in polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in-vitro fertilization cycle

R. Orvieto, V. Shuhat, G. Liberty, R. Homburg, E. Y. Anteby, R. Nahum, J. Rabinson, S. Meltcer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Aims: To determine serum retinol-binding rotein 4 (RBP-4) levels in polycystic ovary syndrome (PCOS) patients undergoing controlled ovarian hyperstimulation (COH) for an in vitro fertilization-embryo transfer (IVF-ET) cycle and the possible correlation to COH variables. Patients and Methods: 11 consecutive PCOS patients undergoing our routine IVF flexible multidose gonadotropin-releasing hormone (GnRH)-antagonist protocol. Blood was drawn three times during the COH cycle: (1) day 1 or 2 of menstruation, and prior to gonadotropin administration (Day-S) (Day-S); (2) day of or prior to human chorionic gonadotropin (hCG) administration (Day-hCG); and (3) day of ovum pick-up (Day-OPU). Levels of estradiol and serum RBP-4 were compared among the three time points. Serum RBP-4 was measured with a commercial immunoassay. Results: Results showed significantly lower levels of serum RBP-4 on Day-OPU and Day-hCG than on Day-S. Though significant correlations were observed between serum RBP-4 and body mass index, fasting glucose or glucose to insulin ratio, no correlations were found between serum RBP-4 and IVF treatment variables or pregnancy rate. Conclusion: While serum RBP-4 decreases during COH for IVF, there is apparently no correlation of serum RBP-4 levels with IVF treatment variables or outcome.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalClinical and Experimental Obstetrics and Gynecology
Volume37
Issue number2
StatePublished - 1 Jul 2010

Keywords

  • BMI
  • Insulin resistance
  • Ovulation induction
  • PCOS
  • Retinol-binding protein-4
  • Sex steroids

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