Set-ups to induce by light a memory in in-vitro neuronal cultures

Clara Zaccaria, Mattia Mancinelli, Beatrice Vignoli, Ilya Auslender, Paolo Bettotti, Asiye Malkoç, Marco Canossa, Lorenzo Pavesi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


To study the brain and the related neuronal network activity, many attempts were made to design and develop platforms able to induce and record neuronal signals. However, many brain processes - like memory formation and storage - and diseases - like amnesia or epilepsy - need more basic studies. For these, a bottom-up approach is needed, starting from 2D in-vitro neuronal cultures. In this work, we will present two experimental systems able to optogenetically interact with 2D neuronal networks with patternized light. One system consists in a Digital Light Projector (DLP) integrated in a microscope setup, which can illuminate neurons from the top; the other, is a compact and transportable photonic chip, properly designed to illuminate neurons plated on its surface.

Original languageEnglish
Title of host publicationOptogenetics and Optical Manipulation 2022
EditorsSamarendra K. Mohanty, Anna W. Roe, Shy Shoham
ISBN (Electronic)9781510647657
StatePublished - 1 Jan 2022
Externally publishedYes
EventOptogenetics and Optical Manipulation 2022 - San Francisco, United States
Duration: 22 Jan 202223 Jan 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptogenetics and Optical Manipulation 2022
Country/TerritoryUnited States
CitySan Francisco


  • chip
  • digital
  • hybrid
  • interface
  • light
  • neural
  • photonic
  • projection

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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