Setting apart the affected: The use of behavioral criteria in animal models of post traumatic stress disorder

Hagit Cohen, Joseph Zohar, Michael A. Matar, Kaplan Zeev, Uri Loewenthal, Gal Richter-Levin

Research output: Contribution to journalArticlepeer-review

187 Scopus citations

Abstract

Post-traumatic stress disorder (PTSD) affects about 20-30% of exposed individuals. Clinical studies of PTSD generally employ stringent criteria for inclusion in study populations, and yet in animal studies the data collection and analysis are generally expressed as a function of exposed vs nonexposed populations, regardless of individual variation in response. Prior data support an approach to animal models analogous to inclusion criteria in clinical studies. This series of studies sought to assess prevalence rates of maladaptive vs adaptive responses determined according to a more stringent approach to the concept of inclusion/exclusion criteria (cutoff behavioral criteria-CBC), consisting of two successive behavioral tests (elevated plus maze and acoustic startle response tests). The rats were exposed to stressors in two different paradigms; exposure to a predator and underwater trauma. The prevalence rates of maladaptive responses to stress in these two distinct models dropped overtime from 90% in the acute phase to 25% enduring/maladaptive response at 7 days, to remain constant over 30 days. As setting the affected individuals apart from the unaffected approximates clinical studies, it might also help to clarify some of the pending issues in PTSD research.

Original languageEnglish
Pages (from-to)1962-1970
Number of pages9
JournalNeuropsychopharmacology
Volume29
Issue number11
DOIs
StatePublished - 1 Nov 2004

Keywords

  • Acoustic startle response
  • Animal models
  • Anxiety
  • Elevated plus maze
  • Maladapted
  • Post-traumatic stress disorders
  • Predator stress
  • Well adapted

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