Severe, diffuse osteosclerosis: A new manifestation of transitional cell carcinoma of the urinary bladder

Y. Liel; E. Maor; S. Ariad; M. N. Lowenthal

doi:10.1007/s002239900560

Severe, diffuse osteosclerosis: A new manifestation of transitional cell carcinoma of the urinary bladder

Y. Liel, E. Maor, S. Ariad, M. N. Lowenthal

Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum acid phosphatase and prostatic-specific antigen (PSA) were normal. Serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were just below the normal limit and parathyroid hormone was moderately elevated. A translilac bone biopsy specimen revealed expanded bone trabeculae, abundance of osteoidcovered surfaces, and heavy metastatic spread. To the best of our knowledge, this is the first description of the association of osteosclerosis and metastatic transitional-cell carcinoma of the bladder.

Original language	English
Pages (from-to)	471-474
Number of pages	4
Journal	Calcified Tissue International
Volume	63
Issue number	6
DOIs	https://doi.org/10.1007/s002239900560
State	Published - 1 Dec 1998

Keywords

Bladder carcinoma
Osteoblastic bone metastases
Osteosclerosis

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s002239900560

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title = "Severe, diffuse osteosclerosis: A new manifestation of transitional cell carcinoma of the urinary bladder",

abstract = "A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum acid phosphatase and prostatic-specific antigen (PSA) were normal. Serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were just below the normal limit and parathyroid hormone was moderately elevated. A translilac bone biopsy specimen revealed expanded bone trabeculae, abundance of osteoidcovered surfaces, and heavy metastatic spread. To the best of our knowledge, this is the first description of the association of osteosclerosis and metastatic transitional-cell carcinoma of the bladder.",

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TY - JOUR

T1 - Severe, diffuse osteosclerosis

T2 - A new manifestation of transitional cell carcinoma of the urinary bladder

AU - Liel, Y.

AU - Maor, E.

AU - Ariad, S.

AU - Lowenthal, M. N.

PY - 1998/12/1

Y1 - 1998/12/1

N2 - A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum acid phosphatase and prostatic-specific antigen (PSA) were normal. Serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were just below the normal limit and parathyroid hormone was moderately elevated. A translilac bone biopsy specimen revealed expanded bone trabeculae, abundance of osteoidcovered surfaces, and heavy metastatic spread. To the best of our knowledge, this is the first description of the association of osteosclerosis and metastatic transitional-cell carcinoma of the bladder.

AB - A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum acid phosphatase and prostatic-specific antigen (PSA) were normal. Serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were just below the normal limit and parathyroid hormone was moderately elevated. A translilac bone biopsy specimen revealed expanded bone trabeculae, abundance of osteoidcovered surfaces, and heavy metastatic spread. To the best of our knowledge, this is the first description of the association of osteosclerosis and metastatic transitional-cell carcinoma of the bladder.

KW - Bladder carcinoma

KW - Osteoblastic bone metastases

KW - Osteosclerosis

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DO - 10.1007/s002239900560

M3 - Article

C2 - 9817940

AN - SCOPUS:0031741068

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JF - Calcified Tissue International

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ER -

Severe, diffuse osteosclerosis: A new manifestation of transitional cell carcinoma of the urinary bladder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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