Severe hypersensitivity reactions to corticosteroids in children

Amit Nahum, Ben Zion Garty, Nufar Marcus, Tommy Shoenfeld, Yael Levy

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


To present 3 children with hypersensitivity reaction to methylprednisolone sodium-succinate and review the literature regarding such reactions. Data on the clinical features were obtained from the children's files. Skin prick tests were performed with a panel of corticosteroid preparations. Three patients (5, 7, and 8 years) with asthma who were treated with intravenous methylprednisolone acetate at the emergency department developed hypersensitivity reactions initially consider to be due to their primary disease. Two had a positive skin prick test to methylprednisolone sodium succinate but not to other corticosteroids or to the succinate ester. Skin prick tests to different corticosteroids, performed 4 years after the event in the third patient, were negative. Methylprednisolone sodium-succinate may cause anaphylactic/ anaphylactoid reactions in children. Our patients' histories emphasize the importance of awareness to corticosteroid-induced reactions, especially in children with asthma in whom the symptoms may be considered as an exacerbation of their primary illness.

Original languageEnglish
Pages (from-to)339-341
Number of pages3
JournalPediatric Emergency Care
Issue number5
StatePublished - 1 May 2009
Externally publishedYes


  • Anaphylaxis
  • Corticosteroids
  • Hypersensitivity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine


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