Severe oligohydramnios with intact membranes: An indication for diagnostic amnioinfusion

Peter G. Pryde, Mordechai Hallak, Michele R. Lauria, Linda Littman, Sidney F. Bottoms, Mark P. Johnson, Mark I. Evans

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective: To quantify the improvement in ultrasonographic fetal imaging following diagnostic amnioinfusion for the indication of unexplained midtrimester oligohydramnios. Methods: Patients referred for unexplained midtrimester oligohydramnios were retrospectively reviewed. Videotapes of those undergoing diagnostic antenatal amnioinfusion were analyzed for quality of visualization of routinely imaged structures before and after the infusion procedure. Results: The overall rate of adequate visualization of fetal structures improved from 50.98 to 76.79% (p < 0.0001). In fetuses having preinfusion-identified obstructive uropathy, there was improvement in identification of associated anomalies from 11.8 to 31.3%. Conclusions: Several authors have suggested that diagnostic amnioinfusion can facilitate fetal imaging and increase diagnostic precision in the setting of unexplained severe oligohydramnios. We have quantified the improvement in the rate of optimal visualization of fetal structures which likely translates, in experienced hands, into this observed improved diagnostic precision. Of particular importance is the improvement in appreciation of associated anomalies in cases of obstructive uropathy in which such findings may determine whether or not invasive fetal therapy is indicated. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalFetal Diagnosis and Therapy
Issue number1
StatePublished - 1 Jan 2000
Externally publishedYes


  • Amnioinfusion
  • Congenital anomalies
  • Fetal obstructive uropathy
  • Obstetrical ultrasonography
  • Oligohydramnios
  • Prenatal diagnosis/therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology


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