Sex Differences in Infective Endocarditis

Ilya Polishchuk, Vered Stavi, Jenan Awesat, Yael Ben Baruch Golan, Carmi Bartal, Iftach Sagy, Alan Jotkowitz, Leonid Barski

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: The impact of sex on the presentation, etiology, and outcomes of infective endocarditis (IE) has not been adequately studied. The aim of the present research was to analyze the impact of sex on the presentation, etiology, and outcomes of IE. Methods: We performed a retrospective study of 214 adult patients (131 male and 83 female) with IE. All cases of IE were reviewed by two investigators- both senior physicians in internal medicine. Two groups of patients were compared: male and female patients with IE. The primary outcome was in-hospital mortality. Results: We found significant differences in etiologic factors of IE in male and female patients. Microbiologic etiology differences between male and female groups of patients were in coagulase negative staphylococcus (15.0% in male vs 3.8% in female groups, P = 0.011), and culture negative endocarditis (8.7% in male vs 23.8% in female groups, P = 0.004). We did not find a difference in the primary outcome between the two groups; however, all-cause mortality was significantly higher in the female group as compared to the male group (26 [31.3] vs 22 [16.8], P = 0.018). Conclusions: We found that sex may have important role in both the microbial profile and the patient's outcome with IE.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalAmerican Journal of the Medical Sciences
Issue number1
StatePublished - 1 Jan 2021


  • Infective Endocarditis
  • Sex differences in etiology
  • Sex differences in outcomes

ASJC Scopus subject areas

  • General Medicine


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