Shaping photomechanical effects in tissue ablation using 355 nm laser pulses

Amir Herzog, Idan Steinberg, Amiel A. Ishaaya

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We investigate the influence of the cladding diameter of an optical delivery fiber on the ablation dynamics of porcine aorta immersed in tetracycline antibiotic solution using 355 nm nanosecond pulses. We manipulate the pressure transients by enforcing a rear rigid interface (applied by an enlargement of the cladding diameter) to the ablated area, which leads to enhanced ablation efficiency along with a reduction in tissue disruption effects. Numerical simulations, based on the finite elements method, are used to study the propagation of the pressure transients within the suggested scheme. Ultrasonic transducers are used for measuring the increased pressure in front of the fiber's facet and the reduced pressure at the fiber's circumference in the presence of large diameter cladding. The increase and decrease are both found to be by a factor of ˜1.8. The width of the cavitation bubble is measured by high-speed photography. An enlargement of 13.8% is demonstrated, at the expense of backward expansion along the fiber's axis. A histopathological in vitro study demonstrates an average enhancement of 12.27% in the diameter of the ablated crater, as well as significant reduction in the disruption effects. Our study sheds light on the potential to improve the ablation efficiency without additional energy cost, along with attaining improved safety for interventional medical procedures. (Figure presented.).

Original languageEnglish
Pages (from-to)1262-1270
Number of pages9
JournalJournal of Biophotonics
Issue number10
StatePublished - 1 Oct 2017


  • 355 nm
  • cavitation bubble
  • laser ablation
  • photomechanical effects

ASJC Scopus subject areas

  • Chemistry (all)
  • Materials Science (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • Engineering (all)
  • Physics and Astronomy (all)


Dive into the research topics of 'Shaping photomechanical effects in tissue ablation using 355 nm laser pulses'. Together they form a unique fingerprint.

Cite this