ShcC proteins: Brain aging and beyond

Orli Sagi, Arie Budovsky, Marina Wolfson, Vadim E. Fraifeld

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


To date, most studies of Shc family of signaling adaptor proteins have been focused on the near-ubiquitously expressed ShcA, indicating its relevance to age-related diseases and longevity. Although the role of the neuronal ShcC protein is much less investigated, accumulated evidence suggests its importance for neuroprotection against such aging-associated conditions as brain ischemia and oxidative stress. Here, we summarize more than decade of studies on the ShcC expression and function in normal brain, age-related brain pathologies and immune disorders with a focus on the interactions of ShcC with signaling proteins/pathways, and the possible implications of these interactions for changes associated with aging.

Original languageEnglish
Pages (from-to)34-42
Number of pages9
JournalAgeing Research Reviews
StatePublished - 1 Jan 2015


  • Aging
  • Brain ischemia
  • Brain tumors
  • Immunity
  • ShcC adaptor proteins
  • Signaling

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology


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