Short Communication: Effect Of Heat Acclimation And Heat Shock On Oscillations Of Carbamyl-Choline-Evoked Ca Signal In Hsy Cell Line

Pavel Kaspler; Michal Horowitz; Arie Moran

doi:10.1515/JBCPP.1999.10.2.153

Short Communication: Effect Of Heat Acclimation And Heat Shock On Oscillations Of Carbamyl-Choline-Evoked Ca Signal In Hsy Cell Line

Pavel Kaspler, Michal Horowitz, Arie Moran

Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We studied effects of heat acclimation (HA) and acute heat stress (HS) on Ca²⁺signal oscillations following supramaximal carbamyl-choline (CCh) stimulation, using HSY cell line as a model. In the control cells, oscillations decreased their amplitude with time. HS alone did not change either oscillation amplitude or frequency, although calcium release to the cytosol upon CCh stimulation was faster. HA increased maximal oscillation amplitude only. There was no change in basal cytosolic calcium level and peak evoked signal in all experimental conditions. Collectively, the data suggest that HA affects the oscillation profile. Changes in the oscillation profile did not correlate with changes in the resting and evoked Ca²⁺signal, which suggests that the oscillations are a separate target for heat acclimation.

Original language	English
Pages (from-to)	153-161
Number of pages	9
Journal	Journal of Basic and Clinical Physiology and Pharmacology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1515/JBCPP.1999.10.2.153
State	Published - 1 Jan 1999

Keywords

calcium signal oscillations
heat acclimation
heat shock
HSY cell line

ASJC Scopus subject areas

Physiology
Pharmacology
Drug Discovery

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10.1515/JBCPP.1999.10.2.153

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title = "Short Communication: Effect Of Heat Acclimation And Heat Shock On Oscillations Of Carbamyl-Choline-Evoked Ca Signal In Hsy Cell Line",

abstract = "We studied effects of heat acclimation (HA) and acute heat stress (HS) on Ca2+signal oscillations following supramaximal carbamyl-choline (CCh) stimulation, using HSY cell line as a model. In the control cells, oscillations decreased their amplitude with time. HS alone did not change either oscillation amplitude or frequency, although calcium release to the cytosol upon CCh stimulation was faster. HA increased maximal oscillation amplitude only. There was no change in basal cytosolic calcium level and peak evoked signal in all experimental conditions. Collectively, the data suggest that HA affects the oscillation profile. Changes in the oscillation profile did not correlate with changes in the resting and evoked Ca2+signal, which suggests that the oscillations are a separate target for heat acclimation.",

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N2 - We studied effects of heat acclimation (HA) and acute heat stress (HS) on Ca2+signal oscillations following supramaximal carbamyl-choline (CCh) stimulation, using HSY cell line as a model. In the control cells, oscillations decreased their amplitude with time. HS alone did not change either oscillation amplitude or frequency, although calcium release to the cytosol upon CCh stimulation was faster. HA increased maximal oscillation amplitude only. There was no change in basal cytosolic calcium level and peak evoked signal in all experimental conditions. Collectively, the data suggest that HA affects the oscillation profile. Changes in the oscillation profile did not correlate with changes in the resting and evoked Ca2+signal, which suggests that the oscillations are a separate target for heat acclimation.

AB - We studied effects of heat acclimation (HA) and acute heat stress (HS) on Ca2+signal oscillations following supramaximal carbamyl-choline (CCh) stimulation, using HSY cell line as a model. In the control cells, oscillations decreased their amplitude with time. HS alone did not change either oscillation amplitude or frequency, although calcium release to the cytosol upon CCh stimulation was faster. HA increased maximal oscillation amplitude only. There was no change in basal cytosolic calcium level and peak evoked signal in all experimental conditions. Collectively, the data suggest that HA affects the oscillation profile. Changes in the oscillation profile did not correlate with changes in the resting and evoked Ca2+signal, which suggests that the oscillations are a separate target for heat acclimation.

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Short Communication: Effect Of Heat Acclimation And Heat Shock On Oscillations Of Carbamyl-Choline-Evoked Ca Signal In Hsy Cell Line

Abstract

Keywords

ASJC Scopus subject areas

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