Should soybean agglutinin purging be performed in breast cancer patients undergoing autologous stem cell transplantation?

Rami Ben-Yosef, Reuven Or, Ella Naparstek, Joseph Kapelushnik, Simcha Samuels, Shimon Slavin, Arnon Nagler

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


High-dose chemotherapy (HDC) followed by autologous stem cell transplantation (ASCT) has gained an increasing role in the treatment of high-risk Stage II-III and/or metastatic breast cancer patients. Several investigators reported on a high rate of tumor cells contaminating the bone marrow and peripheral blood stem cell collection. Nevertheless, the clinical implication of reinfusion of tumor cells with the stem cells to the relapse rate is still uncertain. In this retrospective analysis we compare the outcome and the toxicity of 29 patients with high-risk Stage II-III and 19 metastatic breast cancer patients who underwent HDC with ASCT. Thirteen patients underwent transplant with soybean agglutinin (SBA)-purged graft, while 35 consecutive patients received unmanipulated graft. Engraftment was significantly faster for the nonpurged transplant. No differences in disease- free survival, freedom from relapse, or overall survival were noted in both groups during a median follow up time of 14 months. We conclude that tumor cell purging using SBA in breast cancer patients is not warranted. New purging methods are needed to assess the role of tumor cell purging in breast cancer patients.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number4
StatePublished - 1 Aug 1997
Externally publishedYes


  • Autologous stem cell transplantation
  • Breast cancer
  • High-dose chemotherapy
  • Purging

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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