Should we offer in vitro fertilization to couples with unexplained recurrent pregnancy loss?

In clinical practice, empirical treatments are often offered to couples with recurrent pregnancy loss, including in vitro fertilization. Given that most patients with recurrent pregnancy loss are fertile, the scientific rationale of in vitro fertilization for these couple is debatable. This review will discuss the potential benefits of using in vitro fertilization in couples with recurrent pregnancy loss, such as shortening the time to conceive, optimizing the timing of conception, improving gamete and embryo quality, endometrial receptivity and the use of “adds-on”. At present, there is not enough evidence to justify IVF as a treatment option in couples with unexplained recurrent pregnancy loss.