Signal transduction and intracellular events in T-lymphocyte activation

Noah Isakov, Wolfgang Scholz, Amnon Altman

Research output: Contribution to journalReview articlepeer-review

116 Scopus citations


The important role of a novel signal transduction pathway has recently been established in the cellular activation and proliferation of many cell types. The key event in this pathway is the hydrolysis of a distinct membrane-associated inositol phospholipid and the resulting generation of two defined products that act as second messengers in cell activation. Sufficient evidence has accumulated to indicate that this signal transduction pathway plays an important role in T-cell activation. In this article, Noah Isakov and his colleagues review briefly the general characteristics of this pathway and describe in more detail experimental evidence that establishes its critical role in T-cell activation.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalImmunology Today
Issue number9
StatePublished - 1 Jan 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


Dive into the research topics of 'Signal transduction and intracellular events in T-lymphocyte activation'. Together they form a unique fingerprint.

Cite this