Signature amyloid β profiles are produced by different γ-secretase complexes

Hermien Acx; Lucía Chávez-Gutiérrez; Lutgarde Serneels; Sam Lismont; Manasi Benurwar; Nadav Elad; Bart De Strooper

doi:10.1074/jbc.M113.530907

Signature amyloid β profiles are produced by different γ-secretase complexes

Hermien Acx
, Lucía Chávez-Gutiérrez
, Lutgarde Serneels
, Sam Lismont
, Manasi Benurwar
, Nadav Elad
, Bart De Strooper

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Background: γ-Secretase complexes generate amyloid-β (Aβ) in Alzheimer disease. Results: Aβ profiles of the four γ-secretase complexes expressed in humans show that PSEN regulates total peptide levels and the Aβ38 pathway, whereas APH1 affects mainly the efficiency of the carboxypeptidase-like activity. Conclusion: γ-Secretase subunit composition regulates Aβ generation. Significance: These intrinsic differences could be used to advance AD therapeutic development.

Original language	English
Pages (from-to)	4346-4355
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.530907
State	Published - 14 Feb 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.530907

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abstract = "Background: γ-Secretase complexes generate amyloid-β (Aβ) in Alzheimer disease. Results: Aβ profiles of the four γ-secretase complexes expressed in humans show that PSEN regulates total peptide levels and the Aβ38 pathway, whereas APH1 affects mainly the efficiency of the carboxypeptidase-like activity. Conclusion: γ-Secretase subunit composition regulates Aβ generation. Significance: These intrinsic differences could be used to advance AD therapeutic development.",

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AU - Acx, Hermien

AU - Chávez-Gutiérrez, Lucía

AU - Serneels, Lutgarde

AU - Lismont, Sam

AU - Benurwar, Manasi

AU - Elad, Nadav

AU - De Strooper, Bart

PY - 2014/2/14

Y1 - 2014/2/14

N2 - Background: γ-Secretase complexes generate amyloid-β (Aβ) in Alzheimer disease. Results: Aβ profiles of the four γ-secretase complexes expressed in humans show that PSEN regulates total peptide levels and the Aβ38 pathway, whereas APH1 affects mainly the efficiency of the carboxypeptidase-like activity. Conclusion: γ-Secretase subunit composition regulates Aβ generation. Significance: These intrinsic differences could be used to advance AD therapeutic development.

AB - Background: γ-Secretase complexes generate amyloid-β (Aβ) in Alzheimer disease. Results: Aβ profiles of the four γ-secretase complexes expressed in humans show that PSEN regulates total peptide levels and the Aβ38 pathway, whereas APH1 affects mainly the efficiency of the carboxypeptidase-like activity. Conclusion: γ-Secretase subunit composition regulates Aβ generation. Significance: These intrinsic differences could be used to advance AD therapeutic development.

UR - https://www.scopus.com/pages/publications/84894188617

U2 - 10.1074/jbc.M113.530907

DO - 10.1074/jbc.M113.530907

M3 - Article

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JF - Journal of Biological Chemistry

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Signature amyloid β profiles are produced by different γ-secretase complexes

Abstract

ASJC Scopus subject areas

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