Similar incidences of TP53 deletions in extramedullary organ infiltrations, soft tissue and osteolyses of patients with multiple myeloma

Lisa Billecke, Eva Maria Murga Penas, Annette M. May, Monika Engelhardt, Arnon Nagler, Merav Leiba, Ginette Schiby, Nicolaus Kröger, Jozef Zustin, Andreas Marx, Jakob Matschke, Markus Tiemann, Eray Goekkurt, Carsten Bokemeyer, Georgia Schilling

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: Extramedullary (EM) organ impairment in patients with multiple myeloma (MM) is a rare event, occurring mostly during disease relapse after high-dose chemotherapy with autologous or allogeneic stem cell transplantation. This manifestation is commonly associated with an unfavourable outcome. Previous studies suggested a correlation between the clinical course of patients with MM and EM and the cytogenetic findings, e.g. deletion of TP53 on 17p13. Materials and Methods: We investigated patients with these rare plasma cell organ infiltrations (n=17) as well as bone lesions or soft tissue lesions, known to be a common clinical feature of MM (n=14), using a newly established method of fluorescence in situ hybridization in combination with cytoplasmic immunoglobulin staining (cIg-FISH) on paraffin-embedded sections and a specific probe for TP53 on 17p13. Results and Conclusion: The incidence of del(17)(p13) was similar in both groups but overall it was higher when compared to published data obtained from bone marrow samples and material originating from osteolyses. Further investigations on a larger patient cohort are needed in order to confirm these findings.

Original languageEnglish
Pages (from-to)2031-2034
Number of pages4
JournalAnticancer Research
Volume32
Issue number5
StatePublished - 1 May 2012
Externally publishedYes

Keywords

  • Cytogenetics
  • Del (17)(p13)
  • Extramedullary myeloma
  • Fluorescence in situ hybridization
  • Multiple myeloma
  • TP53
  • cIg-FISH

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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