We present a preliminary concept of simulation-based optimization methodology framework for designing workspace with exoskeleton. The framework consists of three main elements human (ergonomic performance), workspace (industrial tasks, sub-tasks, environment, safety) and exoskeleton (assistance levels, robustness, workspace, imposed constraints), mathematical models and interactions that can converge to an optimal solution i.e. workspace design recommendations. We select the changing the drill bit in for the vertical drilling machine as an industrial task. The human and workspace mathematical modelling is performed using the Jack software and Process Simulate software. In future, we will focus on developing exoskeleton mathematical model and establish mathematical interaction between human model and the exoskeleton model.