TY - GEN
T1 - Simulation of the prokaryotic cell cycle at http://simon.bio.uva.nl/ cellcycle/
AU - Zaritsky, Arieh
AU - Woldringh, Conrad L.
AU - Vischer, Norbert O.E.
AU - Helmstetter, Charles E.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - The bacterial cell cycle is presented using the Simulation program CCSim, which employs four parameters related to time (inter-division r, replication C, division D) and size (mass at replication initiation Mi), sufficient to describe and compare bacterial cells under various conditions. The simulation is easy to use and presents the kinetics of cell growth in an easily digestible format. Animation of a replicating chromosome and growing bacterium are coupled to parameters that affect the cell cycle. The values of these parameters can be altered and the effects of these alterations can be seen. CCSim serves as an educational tool to teach bacteriology at undergraduate level and to compare experimental observations with the best available model describing cell growth hence improve our understanding of regulatory mechanisms. Examples are displayed of several transitions between known physiological states that are consistent with experimental results, including one that explains strange observations.
AB - The bacterial cell cycle is presented using the Simulation program CCSim, which employs four parameters related to time (inter-division r, replication C, division D) and size (mass at replication initiation Mi), sufficient to describe and compare bacterial cells under various conditions. The simulation is easy to use and presents the kinetics of cell growth in an easily digestible format. Animation of a replicating chromosome and growing bacterium are coupled to parameters that affect the cell cycle. The values of these parameters can be altered and the effects of these alterations can be seen. CCSim serves as an educational tool to teach bacteriology at undergraduate level and to compare experimental observations with the best available model describing cell growth hence improve our understanding of regulatory mechanisms. Examples are displayed of several transitions between known physiological states that are consistent with experimental results, including one that explains strange observations.
KW - Coupling between chromosome replication and cell division
KW - Duplication of the nucleoid and the sacculus
KW - In silico simulation
KW - Temporal and spatial regulation
KW - The bacterial cell cycle
UR - http://www.scopus.com/inward/record.url?scp=84896283692&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84896283692
SN - 9781936338337
T3 - IMSCI 2011 - 5th International Multi-Conference on Society, Cybernetics and Informatics, Proceedings
SP - 147
EP - 151
BT - IMSCI 2011 - 5th International Multi-Conference on Society, Cybernetics and Informatics, Proceedings
PB - International Institute of Informatics and Systemics, IIIS
T2 - 5th International Multi-Conference on Society, Cybernetics and Informatics, IMSCI 2011
Y2 - 19 July 2011 through 22 July 2011
ER -