Simultaneous Noninvasive Detection and Therapy of Atherosclerosis Using HDL Coated Gold Nanorods

Rinat Ankri, Dorit Leshem-Lev, Hamootal Duadi, Emanuel Harari, Menachem Motiei, Edith Hochhauser, Eli I. Lev, Dror Fixler

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Cardiovascular disease (CVD) is a major cause of death and disability worldwide. A real need exists in the development of new, improved therapeutic methods for treating CVD, while major advances in nanotechnology have opened new avenues in this field. In this paper, we report the use of gold nanoparticles (GNPs) coated with high-density lipoprotein (HDL) (GNP-HDL) for the simultaneous detection and therapy of unstable plaques. Based on the well-known HDL cardiovascular protection, by promoting the reverse cholesterol transport (RCT), injured rat carotids, as a model for unstable plaques, were injected with the GNP-HDL. Noninvasive detection of the plaques 24 h post the GNP injection was enabled using the diffusion reflection (DR) method, indicating that the GNP-HDL particles had accumulated in the injured site. Pathology and noninvasive CT measurements proved the recovery of the injured artery treated with the GNP-HDL. The DR of the GNP-HDL presented a simple and highly sensitive method at a low cost, resulting in simultaneous specific unstable plaque diagnosis and recovery.

    Original languageEnglish
    Article number577
    JournalDiagnostics
    Volume12
    Issue number3
    DOIs
    StatePublished - 1 Mar 2022

    Keywords

    • Atherosclerosis
    • Diffusion reflection
    • Gold nanorods
    • High-density lipoprotein
    • Noninvasive imaging
    • Unstable plaques

    ASJC Scopus subject areas

    • Clinical Biochemistry

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