Single chain variants of the glycoprotein hormones and their receptors as tools to study receptor activation and for analogue design

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Abstract

One of the crucial steps in the biosynthesis of multisubunit proteins is their assembly. The glycoprotein hormone, thyroid-stimulating hormone, and the gonadotropins, luteinizing hormone, follicle-stimulating hormone and chorionic gonadotropin, are noncovalent heterodimers. Their assembly is critical for bioactivity because the heterodimers, but not the monomeric subunits, efficiently bind to and activate the cognate heptahelical receptor. Occasionally, mutated subunits cannot combine into a functional hormone, or the bioactivity of the assembled, yet modified, heterodimer is suboptimal.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalJournal of Neuroendocrinology
Volume16
Issue number2
DOIs
StatePublished - 1 Feb 2004

Keywords

  • Gonadotropins
  • Potent analogues
  • Receptor activation

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