Single-molecule studies of DNA and DNA-protein interactions

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Two experiments are described that examine the properties of a single DNA molecule. The experimental system is based on optical tweezers and on a protocol that allows to attach one end of the DNA molecule to the bottom of the sample and the other to a bead of micron size. First, the reaction of the RecA protein with DNA is monitored in a particular DNA molecule. This is made possible by the fact that the DNA is locally extended by a factor of 1.5 whenever a RecA molecule binds. Second, we monitor the dynamics of a DNA molecule as it relaxes from a fully stretched state to the coil configuration.

Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalPhysica E: Low-Dimensional Systems and Nanostructures
Issue number3
StatePublished - 1 Jan 2001

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics


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