TY - JOUR
T1 - Single-Nucleotide Polymorphisms in IL23R-IL12RB2 (rs1495965) Are Highly Prevalent in Patients with Behcet’s Uveitis and Vary Between Populations
AU - Kramer, Michal
AU - Hasanreisoglu, Murat
AU - Weiss, Shirel
AU - Kumova, Deniz
AU - Schaap-Fogler, Michal
AU - Guntekin-Ergun, Sezen
AU - Ozdek, Sengul
AU - Gurelik, Gokhan
AU - Ergün, Mehmet Ali
AU - Goldenberg-Cohen, Nitza
AU - Cohen, Yoram
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: To test the frequency of single-nucleotide polymorphisms in the IL-10, IL23R-IL12RB2 genes in patients with Behcet’s uveitis. Methods: Blood samples were collected from 89 Israeli and Turkish patients, and from healthy control subjects of different origins. Genomic DNA was extracted from peripheral blood leukocytes and genotyped. Results: The risk allele, A, in rs1800871, of IL-10 gene was highly prevalent in Behcet’s uveitis and healthy control samples alike; highest among the Turkish groups. Prevalence of G allele, in rs1495965, in the IL23R-IL12RB2 gene was high in Behcet’s uveitis patients, and among healthy Turkish and Israelis of Middle Eastern origin, while lower among the other Israeli control group (77.9%, 78.9%, 27.8%, respectively, P < 0.001). Conclusion: Our findings highlight the differences between populations and may account for the increased prevalence of the disease among Turkish and Israelis of Middle Eastern origin. Further studies are required to map other healthy and affected populations.
AB - Purpose: To test the frequency of single-nucleotide polymorphisms in the IL-10, IL23R-IL12RB2 genes in patients with Behcet’s uveitis. Methods: Blood samples were collected from 89 Israeli and Turkish patients, and from healthy control subjects of different origins. Genomic DNA was extracted from peripheral blood leukocytes and genotyped. Results: The risk allele, A, in rs1800871, of IL-10 gene was highly prevalent in Behcet’s uveitis and healthy control samples alike; highest among the Turkish groups. Prevalence of G allele, in rs1495965, in the IL23R-IL12RB2 gene was high in Behcet’s uveitis patients, and among healthy Turkish and Israelis of Middle Eastern origin, while lower among the other Israeli control group (77.9%, 78.9%, 27.8%, respectively, P < 0.001). Conclusion: Our findings highlight the differences between populations and may account for the increased prevalence of the disease among Turkish and Israelis of Middle Eastern origin. Further studies are required to map other healthy and affected populations.
KW - Behcet’s disease
KW - IL-10
KW - IL23R-IL12RB2
KW - SNP
KW - uveitis
UR - http://www.scopus.com/inward/record.url?scp=85047440011&partnerID=8YFLogxK
U2 - 10.1080/09273948.2018.1467463
DO - 10.1080/09273948.2018.1467463
M3 - Article
C2 - 29792538
AN - SCOPUS:85047440011
SN - 0927-3948
VL - 27
SP - 766
EP - 773
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 5
ER -