SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, Matan Y. Avivi, Asael Roichman, Yariv Kanfi, Asaf A. Gertler, Tirza Doniger, Olga R. Ilkayeva, Ifat Abramovich, Orly Yaron, Batia Lerrer, Eyal Gottlieb, Robert A. Harris, Doron Gerber, Matthew D. HirscheyHaim Y. Cohen

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

Original languageEnglish
Pages (from-to)4127-4143.e8
JournalCell Reports
Issue number12
StatePublished - 17 Dec 2019
Externally publishedYes


  • PPARα
  • SIRT6
  • beta-oxidation
  • deacetylase
  • fasting
  • liver

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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