Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects

Keyphrases

• Deleterious Effects 100%
• Ubiquitination 100%
• Huntingtin 100%
• Cellular Response 66%
• Exon 1 66%
• Huntington's Disease 66%
• Proteomic Analysis 66%
• Attenuation 33%
• Motor Symptoms 33%
• Triplet 33%
• Cortical Neurons 33%
• Neurodegenerative Diseases 33%
• Neuroimaging 33%
• Transgenic Animals 33%
• Brain Tissue 33%
• Protein Drug 33%
• First Exons 33%
• Neuron Cells 33%
• Rat Model 33%
• Guanine 33%
• Death Rate 33%
• N-terminal Domain 33%
• Cultured Cells 33%
• Striatal 33%
• Neuropsychiatric Symptoms 33%
• Cytosine 33%
• Lysine Residue 33%
• Proteasomal Degradation 33%
• Ubiquitination Sites 33%
• Ubiquitin-proteasome System 33%
• Cortical Brain 33%
• Aggregation-prone 33%
• Polyglutamine 33%
• Proteotoxic Stress 33%
• Pathogenic Effects 33%
• Appearance Rate 33%

Neuroscience

• Ubiquitination 100%
• Huntingtin 100%
• Exon 75%
• Huntington's Disease 50%
• Proteomics 50%
• Lysine 25%
• Neurodegenerative Disorder 25%
• Cell Culture 25%
• Amino Terminal Sequence 25%
• Adenine 25%
• Ubiquitin 25%
• Proteasome 25%
• Polyglutamine 25%
• Guanine 25%
• Cytosine 25%

Biochemistry, Genetics and Molecular Biology

• Ubiquitination 100%
• Huntingtin 100%
• Exon 75%
• Proteomics 50%
• Cell Culture 25%
• Mortality Rate 25%
• N-Terminus 25%
• Lysine 25%
• Rat Model 25%
• Guanine 25%
• Adenine 25%
• Proteasome 25%
• Transgenic Animal 25%
• Ubiquitin 25%
• Cytosine 25%