For the first time SnCl2·2H2O has been identified as a convenient precatalyst for the synthesis of pyridine derivatives via an MCR in water. The 4-component reaction of alkyl/(hetero)aryl aldehydes, β-keto esters (or 1,3-diketones), anilines, and malononitrile afforded a range of new polysubstituted pyridines including 4-alkyl/heteroaryl derivatives in 78-91% yields. The use of less expensive catalyst in aqueous media and good yields of products with wider substrate scope are the key features of this methodology.
|Number of pages||4|
|State||Published - 29 Jun 2015|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry