Solar insolation in springtime influences age of onset of bipolar I disorder

M. Bauer; T. Glenn; M. Alda; M. A. Aleksandrovich; O. A. Andreassen; E. Angelopoulos; R. Ardau; Y. Ayhan; C. Baethge; S. R. Bharathram; R. Bauer; B. T. Baune; C. Becerra-Palars; F. Bellivier; R. H. Belmaker; M. Berk; Y. Bersudsky; Bicakci; H. Birabwa-Oketcho; T. D. Bjella; L. Bossini; J. Cabrera; E. Y.W. Cheung; M. Del Zompo; S. Dodd; M. Donix; B. Etain; A. Fagiolini; K. N. Fountoulakis; M. A. Frye; A. Gonzalez-Pinto; J. F. Gottlieb; P. Grof; H. Harima; C. Henry; E. T. Isometsä; S. Janno; F. Kapczinski; M. Kardell; S. Khaldi; S. Kliwicki; B. König; T. L. Kot; R. Krogh; M. Kunz; B. Lafer; M. Landén; E. R. Larsen; U. Lewitzka; R. W. Licht; C. Lopez-Jaramillo; G. MacQueen; M. Manchia; W. Marsh; M. Martinez-Cengotitabengoa; I. Melle; F. Meza-Urzúa; M. Yee Ming; S. Monteith; G. Morken; E. Mosca; R. Munoz; S. V. Mythri; F. Nacef; R. K. Nadella; F. G. Nery; R. E. Nielsen; C. O'Donovan; A. Omrani; Y. Osher; H. Østermark Sørensen; U. Ouali; Y. Pica Ruiz; M. Pilhatsch; M. Pinna; F. D.R. da Ponte; D. Quiroz; R. Ramesar; N. Rasgon; M. S. Reddy; A. Reif; P. Ritter; J. K. Rybakowski; K. Sagduyu; M. Scippa; E. Severus; C. Simhandl; D. J. Stein; S. Strejilevich; M. Subramaniam; A. H. Sulaiman; K. Suominen; H. Tagata; Y. Tatebayashi; L. Tondo; C. Torrent; A. E. Vaaler; J. Veeh; E. Vieta; B. Viswanath; M. Yoldi-Negrete; M. Zetin; Y. Zgueb; P. C. Whybrow

doi:10.1111/acps.12772

Solar insolation in springtime influences age of onset of bipolar I disorder

M. Bauer, T. Glenn, M. Alda, M. A. Aleksandrovich, O. A. Andreassen, E. Angelopoulos, R. Ardau, Y. Ayhan, C. Baethge, S. R. Bharathram, R. Bauer, B. T. Baune, C. Becerra-Palars, F. Bellivier, R. H. Belmaker, M. Berk, Y. Bersudsky, Bicakci, H. Birabwa-Oketcho, T. D. BjellaL. Bossini, J. Cabrera, E. Y.W. Cheung, M. Del Zompo, S. Dodd, M. Donix, B. Etain, A. Fagiolini, K. N. Fountoulakis, M. A. Frye, A. Gonzalez-Pinto, J. F. Gottlieb, P. Grof, H. Harima, C. Henry, E. T. Isometsä, S. Janno, F. Kapczinski, M. Kardell, S. Khaldi, S. Kliwicki, B. König, T. L. Kot, R. Krogh, M. Kunz, B. Lafer, M. Landén, E. R. Larsen, U. Lewitzka, R. W. Licht, C. Lopez-Jaramillo, G. MacQueen, M. Manchia, W. Marsh, M. Martinez-Cengotitabengoa, I. Melle, F. Meza-Urzúa, M. Yee Ming, S. Monteith, G. Morken, E. Mosca, R. Munoz, S. V. Mythri, F. Nacef, R. K. Nadella, F. G. Nery, R. E. Nielsen, C. O'Donovan, A. Omrani, Y. Osher, H. Østermark Sørensen, U. Ouali, Y. Pica Ruiz, M. Pilhatsch, M. Pinna, F. D.R. da Ponte, D. Quiroz, R. Ramesar, N. Rasgon, M. S. Reddy, A. Reif, P. Ritter, J. K. Rybakowski, K. Sagduyu, M. Scippa, E. Severus, C. Simhandl, D. J. Stein, S. Strejilevich, M. Subramaniam, A. H. Sulaiman, K. Suominen, H. Tagata, Y. Tatebayashi, L. Tondo, C. Torrent, A. E. Vaaler, J. Veeh, E. Vieta, B. Viswanath, M. Yoldi-Negrete, M. Zetin, Y. Zgueb, P. C. Whybrow

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Abstract

Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

Original language	English
Pages (from-to)	571-582
Number of pages	12
Journal	Acta Psychiatrica Scandinavica
Volume	136
Issue number	6
DOIs	https://doi.org/10.1111/acps.12772
State	Published - 1 Dec 2017

Keywords

bipolar disorder
circadian rhythm
epidemiology
solar insolation

ASJC Scopus subject areas

Psychiatry and Mental health

Access to Document

10.1111/acps.12772

Cite this

Bauer, M., Glenn, T., Alda, M., Aleksandrovich, M. A., Andreassen, O. A., Angelopoulos, E., Ardau, R., Ayhan, Y., Baethge, C., Bharathram, S. R., Bauer, R., Baune, B. T., Becerra-Palars, C., Bellivier, F., Belmaker, R. H., Berk, M., Bersudsky, Y., Bicakci, Birabwa-Oketcho, H., ... Whybrow, P. C. (2017). Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica, 136(6), 571-582. https://doi.org/10.1111/acps.12772

@article{0ac1f78ae20a48cab77498fd90131e09,

title = "Solar insolation in springtime influences age of onset of bipolar I disorder",

abstract = "Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.",

keywords = "bipolar disorder, circadian rhythm, epidemiology, solar insolation",

author = "M. Bauer and T. Glenn and M. Alda and Aleksandrovich, {M. A.} and Andreassen, {O. A.} and E. Angelopoulos and R. Ardau and Y. Ayhan and C. Baethge and Bharathram, {S. R.} and R. Bauer and Baune, {B. T.} and C. Becerra-Palars and F. Bellivier and Belmaker, {R. H.} and M. Berk and Y. Bersudsky and Bicakci and H. Birabwa-Oketcho and Bjella, {T. D.} and L. Bossini and J. Cabrera and Cheung, {E. Y.W.} and {Del Zompo}, M. and S. Dodd and M. Donix and B. Etain and A. Fagiolini and Fountoulakis, {K. N.} and Frye, {M. A.} and A. Gonzalez-Pinto and Gottlieb, {J. F.} and P. Grof and H. Harima and C. Henry and Isomets{\"a}, {E. T.} and S. Janno and F. Kapczinski and M. Kardell and S. Khaldi and S. Kliwicki and B. K{\"o}nig and Kot, {T. L.} and R. Krogh and M. Kunz and B. Lafer and M. Land{\'e}n and Larsen, {E. R.} and U. Lewitzka and Licht, {R. W.} and C. Lopez-Jaramillo and G. MacQueen and M. Manchia and W. Marsh and M. Martinez-Cengotitabengoa and I. Melle and F. Meza-Urz{\'u}a and {Yee Ming}, M. and S. Monteith and G. Morken and E. Mosca and R. Munoz and Mythri, {S. V.} and F. Nacef and Nadella, {R. K.} and Nery, {F. G.} and Nielsen, {R. E.} and C. O'Donovan and A. Omrani and Y. Osher and {{\O}stermark S{\o}rensen}, H. and U. Ouali and {Pica Ruiz}, Y. and M. Pilhatsch and M. Pinna and {da Ponte}, {F. D.R.} and D. Quiroz and R. Ramesar and N. Rasgon and Reddy, {M. S.} and A. Reif and P. Ritter and Rybakowski, {J. K.} and K. Sagduyu and M. Scippa and E. Severus and C. Simhandl and Stein, {D. J.} and S. Strejilevich and M. Subramaniam and Sulaiman, {A. H.} and K. Suominen and H. Tagata and Y. Tatebayashi and L. Tondo and C. Torrent and Vaaler, {A. E.} and J. Veeh and E. Vieta and B. Viswanath and M. Yoldi-Negrete and M. Zetin and Y. Zgueb and Whybrow, {P. C.}",

note = "Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2017",

month = dec,

day = "1",

doi = "10.1111/acps.12772",

language = "English",

volume = "136",

pages = "571--582",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

Bauer, M, Glenn, T, Alda, M, Aleksandrovich, MA, Andreassen, OA, Angelopoulos, E, Ardau, R, Ayhan, Y, Baethge, C, Bharathram, SR, Bauer, R, Baune, BT, Becerra-Palars, C, Bellivier, F, Belmaker, RH, Berk, M, Bersudsky, Y, Bicakci, Birabwa-Oketcho, H, Bjella, TD, Bossini, L, Cabrera, J, Cheung, EYW, Del Zompo, M, Dodd, S, Donix, M, Etain, B, Fagiolini, A, Fountoulakis, KN, Frye, MA, Gonzalez-Pinto, A, Gottlieb, JF, Grof, P, Harima, H, Henry, C, Isometsä, ET, Janno, S, Kapczinski, F, Kardell, M, Khaldi, S, Kliwicki, S, König, B, Kot, TL, Krogh, R, Kunz, M, Lafer, B, Landén, M, Larsen, ER, Lewitzka, U, Licht, RW, Lopez-Jaramillo, C, MacQueen, G, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Meza-Urzúa, F, Yee Ming, M, Monteith, S, Morken, G, Mosca, E, Munoz, R, Mythri, SV, Nacef, F, Nadella, RK, Nery, FG, Nielsen, RE, O'Donovan, C, Omrani, A, Osher, Y, Østermark Sørensen, H, Ouali, U, Pica Ruiz, Y, Pilhatsch, M, Pinna, M, da Ponte, FDR, Quiroz, D, Ramesar, R, Rasgon, N, Reddy, MS, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Scippa, M, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Subramaniam, M, Sulaiman, AH, Suominen, K, Tagata, H, Tatebayashi, Y, Tondo, L, Torrent, C, Vaaler, AE, Veeh, J, Vieta, E, Viswanath, B, Yoldi-Negrete, M, Zetin, M, Zgueb, Y & Whybrow, PC 2017, 'Solar insolation in springtime influences age of onset of bipolar I disorder', Acta Psychiatrica Scandinavica, vol. 136, no. 6, pp. 571-582. https://doi.org/10.1111/acps.12772

TY - JOUR

T1 - Solar insolation in springtime influences age of onset of bipolar I disorder

AU - Bauer, M.

AU - Glenn, T.

AU - Alda, M.

AU - Aleksandrovich, M. A.

AU - Andreassen, O. A.

AU - Angelopoulos, E.

AU - Ardau, R.

AU - Ayhan, Y.

AU - Baethge, C.

AU - Bharathram, S. R.

AU - Bauer, R.

AU - Baune, B. T.

AU - Becerra-Palars, C.

AU - Bellivier, F.

AU - Belmaker, R. H.

AU - Berk, M.

AU - Bersudsky, Y.

AU - Bicakci,

AU - Birabwa-Oketcho, H.

AU - Bjella, T. D.

AU - Bossini, L.

AU - Cabrera, J.

AU - Cheung, E. Y.W.

AU - Del Zompo, M.

AU - Dodd, S.

AU - Donix, M.

AU - Etain, B.

AU - Fagiolini, A.

AU - Fountoulakis, K. N.

AU - Frye, M. A.

AU - Gonzalez-Pinto, A.

AU - Gottlieb, J. F.

AU - Grof, P.

AU - Harima, H.

AU - Henry, C.

AU - Isometsä, E. T.

AU - Janno, S.

AU - Kapczinski, F.

AU - Kardell, M.

AU - Khaldi, S.

AU - Kliwicki, S.

AU - König, B.

AU - Kot, T. L.

AU - Krogh, R.

AU - Kunz, M.

AU - Lafer, B.

AU - Landén, M.

AU - Larsen, E. R.

AU - Lewitzka, U.

AU - Licht, R. W.

AU - Lopez-Jaramillo, C.

AU - MacQueen, G.

AU - Manchia, M.

AU - Marsh, W.

AU - Martinez-Cengotitabengoa, M.

AU - Melle, I.

AU - Meza-Urzúa, F.

AU - Yee Ming, M.

AU - Monteith, S.

AU - Morken, G.

AU - Mosca, E.

AU - Munoz, R.

AU - Mythri, S. V.

AU - Nacef, F.

AU - Nadella, R. K.

AU - Nery, F. G.

AU - Nielsen, R. E.

AU - O'Donovan, C.

AU - Omrani, A.

AU - Osher, Y.

AU - Østermark Sørensen, H.

AU - Ouali, U.

AU - Pica Ruiz, Y.

AU - Pilhatsch, M.

AU - Pinna, M.

AU - da Ponte, F. D.R.

AU - Quiroz, D.

AU - Ramesar, R.

AU - Rasgon, N.

AU - Reddy, M. S.

AU - Reif, A.

AU - Ritter, P.

AU - Rybakowski, J. K.

AU - Sagduyu, K.

AU - Scippa, M.

AU - Severus, E.

AU - Simhandl, C.

AU - Stein, D. J.

AU - Strejilevich, S.

AU - Subramaniam, M.

AU - Sulaiman, A. H.

AU - Suominen, K.

AU - Tagata, H.

AU - Tatebayashi, Y.

AU - Tondo, L.

AU - Torrent, C.

AU - Vaaler, A. E.

AU - Veeh, J.

AU - Vieta, E.

AU - Viswanath, B.

AU - Yoldi-Negrete, M.

AU - Zetin, M.

AU - Zgueb, Y.

AU - Whybrow, P. C.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

AB - Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

KW - bipolar disorder

KW - circadian rhythm

KW - epidemiology

KW - solar insolation

UR - http://www.scopus.com/inward/record.url?scp=85025072706&partnerID=8YFLogxK

U2 - 10.1111/acps.12772

DO - 10.1111/acps.12772

M3 - Article

C2 - 28722128

AN - SCOPUS:85025072706

SN - 0001-690X

VL - 136

SP - 571

EP - 582

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 6

ER -

Solar insolation in springtime influences age of onset of bipolar I disorder

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