Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

Muhammad Jbara, Mallikanti Seenaiah, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.

Original languageEnglish
Pages (from-to)12534-12537
Number of pages4
JournalChemical Communications
Volume50
Issue number83
DOIs
StatePublished - 18 Sep 2014

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