Solid-state nucleophilic aromatic substitution reaction of a carboxylic acid cocrystal

M. C. Etter; G. M. Frankenbach; J. Bernstein

doi:10.1016/S0040-4039(01)80463-9

Solid-state nucleophilic aromatic substitution reaction of a carboxylic acid cocrystal

M. C. Etter, G. M. Frankenbach, J. Bernstein

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70 Scopus citations

Abstract

A facile thermally activated aromatic nucleophilic substitution reaction is shown to take place in the solid state in cocrystals of 4-chloro-3,5-dinitrobenzoic acid and 4-aminobenzoic acid. The cocrystals are also made in the solid state by grinding the two acids together at room temperature.

Original language	English
Pages (from-to)	3617-3620
Number of pages	4
Journal	Tetrahedron Letters
Volume	30
Issue number	28
DOIs	https://doi.org/10.1016/S0040-4039(01)80463-9
State	Published - 1 Jan 1989
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Solid-state nucleophilic aromatic substitution reaction of a carboxylic acid cocrystal",

abstract = "A facile thermally activated aromatic nucleophilic substitution reaction is shown to take place in the solid state in cocrystals of 4-chloro-3,5-dinitrobenzoic acid and 4-aminobenzoic acid. The cocrystals are also made in the solid state by grinding the two acids together at room temperature.",

author = "Etter, {M. C.} and Frankenbach, {G. M.} and J. Bernstein",

note = "Funding Information: w: We gratefully acknowledge financial support to MCE by the Office of Naval Research (N00014-86-K-0660) for this work, and Professor Doyle B&ton, University of Minnesota, for crystallographic assistance.",

year = "1989",

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doi = "10.1016/S0040-4039(01)80463-9",

language = "English",

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T1 - Solid-state nucleophilic aromatic substitution reaction of a carboxylic acid cocrystal

AU - Etter, M. C.

AU - Frankenbach, G. M.

AU - Bernstein, J.

N1 - Funding Information: w: We gratefully acknowledge financial support to MCE by the Office of Naval Research (N00014-86-K-0660) for this work, and Professor Doyle B&ton, University of Minnesota, for crystallographic assistance.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - A facile thermally activated aromatic nucleophilic substitution reaction is shown to take place in the solid state in cocrystals of 4-chloro-3,5-dinitrobenzoic acid and 4-aminobenzoic acid. The cocrystals are also made in the solid state by grinding the two acids together at room temperature.

AB - A facile thermally activated aromatic nucleophilic substitution reaction is shown to take place in the solid state in cocrystals of 4-chloro-3,5-dinitrobenzoic acid and 4-aminobenzoic acid. The cocrystals are also made in the solid state by grinding the two acids together at room temperature.

UR - http://www.scopus.com/inward/record.url?scp=0000483629&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(01)80463-9

DO - 10.1016/S0040-4039(01)80463-9

M3 - Article

AN - SCOPUS:0000483629

SN - 0040-4039

VL - 30

SP - 3617

EP - 3620

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

Solid-state nucleophilic aromatic substitution reaction of a carboxylic acid cocrystal

Abstract

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