Solubilization of lycopene in jojoba oil microemulsion

Nissim Garti, Marina Shevachman, Arnon Shani

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The unique properties of jojoba oil make it an essential raw material in the manufacture of cosmetics. New, totally dilutable U-type microemulsions of water, jojoba oil, alcohols, and the nonionic surfactant polyoxyethylene-10EO- oleyl alcohol (Brij 96V) have been formulated recently. Here, these microemulsions are shown to be capable of solubilizing lycopene, a nutraceutical insoluble in water and/or oil, much more effectively than the solvent (or a solvent and surfactant blend) can dissolve them. In water-in-oil (W/O) and oil-in-water (O/W) microemulsions with 10 and 90 wt% water, respectively, the normalized maximal solubilization efficiency α is ca. 20-fold larger than its solubility. The solubilization capacity of the system is mainly surfactant-concentration dependent. The lycopene resides at the interfaces of the W/O and O/W microemulsions and engenders significant structural changes in the organization of the microemulsion droplets. In the absence of lycopene, the droplets are spherical; when lycopene is added, compaction of the droplets and formation of threadlike droplets are observed. On further addition of lycopene, the bridging effect wanes and the droplets revert to a spherical shape. The enhanced solubilization demonstrated for lycopene opens up new options for formulators interested in making liquid and transparent products for cosmetic or pharmaceutical uses.

Original languageEnglish
Pages (from-to)873-877
Number of pages5
JournalJAOCS, Journal of the American Oil Chemists' Society
Volume81
Issue number9
DOIs
StatePublished - 1 Jan 2004

Keywords

  • Brij 96V
  • Jojoba oil
  • Lycopene
  • Microemulsion
  • Solubilization

ASJC Scopus subject areas

  • General Chemical Engineering
  • Organic Chemistry

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