Soluble CD40 ligand levels during controlled ovarian hyperstimulation - A possible culprit of systemic inflammation

Raoul Orvieto, Benny Schachter, Vered Yulzari-roll, Antonio La Marca, Jacob Bar, Benjamin Fisch

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Aim: To investigate the behavior and association of serum sex-steroids and serum CD40 ligand in patients undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). Design: Prospective, observational study. Setting: The IVF unit of an academic medical center. Patients and methods: Blood was drawn three times during the COH cycle from 17 patients undergoing the long gonadotropin-releasing hormone-analog protocol: (i) day on which adequate suppression was obtained (Day-S); (ii) day of or prior to administration of human chorionic gonadotropin (Day-hCG); and (iii) day of ovum pick-up (Day-OPU). Levels of sex steroids and serum CD40 ligand were compared among the three time points. Results: During gonadotropin treatment, serum ovarian sex steroids (estradiol, progesterone, free testosterone and androstenedione) significantly increased while CD40 ligand levels nonsignificantly decreased. After hCG administration, there was a significant increase in the levels of serum CD40 ligand, ovarian androgens, and progesterone, with a significant decrease in estradiol levels. No correlations were observed between CD40 ligand and ovarian sex-steroid levels or other treatment variables. Conclusion: The administration of hCG leads to activation of systemic inflammation, as reflected by CD40 ligand levels. This, in turn, may lead to the development of ovarian hyperstimulation syndrome via several mechanisms, including an increase in several angiogenic factors.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Issue number4
StatePublished - 1 Oct 2006
Externally publishedYes


  • Androgens
  • CD40 ligand
  • COH
  • IVF
  • OHSS
  • Sex steroids

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology


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