Soluble polysaccharide and biomass of red microalga Porphyridium sp. alter intestinal morphology and reduce serum cholesterol in rats

Irit Dvir, Reuven Chayoth, Uriel Sod-Moriah, Shraga Shany, Abraham Nyska, Aliza H. Stark, Zecharia Madar, Shoshana Malis Arad

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

The present study investigated the effects of the red microalga Porphyridium sp. on gastrointestinal physiology and lipid metabolism in male Sprague-Dawley rats. Diets containing dietary fibre from pelleted red microalgal cells (biomass) or their sulfated polysaccharide, pectin or cellulose (control) were fed to rats for a period of 30 d. All three fibre-supplemented diets increased the length of both small intestine and colon, with a significantly greater effect in rats fed the algal polysaccharide. The polysaccharide also increased mucosa and muscularis cross-sectional area of the jejunum, and caused hypertrophy in the muscularis layer. The algal biomass significantly lowered gastrointestinal transit time by 44 % in comparison with the control rats. Serum and mucosal cholecystokinin levels were lower in rats on the pectin and polysaccharide diets, while cholecystokinin levels in rats fed algal biomass were not different from those in the control animals. In comparison with the control diet, all the experimental diets significantly lowered serum cholesterol levels (22-29 %). Feeding of non-fermentable algal poltsaccharide or biomass significantly increased faecal weight and bile acid excretion compared with pectin-fed or control rats. The algal polysaccharide and biomass were thus shown to be potent hypocholesterolaemic agents active at low concentrations in the diet. Both metabolic and morphological changes were observed following consumption of algae, suggesting several possible mechanisms by which the alga affects lipid metabolism. The results presented in the present study encourage the use of red microalga as a functional food.

Original languageEnglish
Pages (from-to)469-476
Number of pages8
JournalBritish Journal of Nutrition
Volume84
Issue number4
DOIs
StatePublished - 1 Jan 2000

Fingerprint

Dive into the research topics of 'Soluble polysaccharide and biomass of red microalga <i>Porphyridium</i> sp. alter intestinal morphology and reduce serum cholesterol in rats'. Together they form a unique fingerprint.

Cite this