Abstract
The aim of the present study was to evaluate whether soluble triggering receptor expressed on myeloid cells (sTREM-1) is present in the cerebrospinal fluid (CSF) of patients with acute meningitis and if its presence can predict bacterial infection. We found elevated levels of sTREM-1 in the CSF of seven of the nine (78%) patients with culture-positive specimens and in none of 12 (0%) patients with culture-negative specimens (sensitivity: 78%; specificity: 100%). The area under the receiver operating characteristic curve for sTREM-1 in the CSF as a predictor for bacterial meningitis was 0.889. This suggests that sTREM-1 is upregulated in the CSF of patients with bacterial meningitis with high specificity and that its presence can potentially assist clinicians in the diagnosis of bacterial meningitis.
Original language | English |
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Pages (from-to) | 647-650 |
Number of pages | 4 |
Journal | European Journal of Clinical Microbiology and Infectious Diseases |
Volume | 26 |
Issue number | 9 |
DOIs | |
State | Published - 1 Sep 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases