Soluble tumour necrosis factor receptors (sTNF-R) and HIV infection: Correlation to CD8+ lymphocytes

A. Kalinkovich, G. Livshits, H. Engelmann, N. Harpaz, R. Burstein, M. Kaminsky, D. Wallach, Z. Bentwich

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The objective of this study was to determine sTNF-R, type I (p55) and type II (p75) in sera of HIV-infected male homosexuals and correlate them to T lymphocyte subpopulations and course of HIV infection. Serum samples were obtained from 39 HIV-1+ asymptomatic male homosexuals, 10 symptomatic (ARC and AIDS) male homosexuals and 44 HIV- non-homosexual healthy controls. sTNF-R levels were determined by ELISA with specific MoAbs and polyclonal antibodies to the sTNF-R proteins. sTNF-RI and II levels were significantly elevated in 72% and 74% respectively of HIV+ asymptomatic male homosexuals and in all of the symptomatic male homosexuals. In sequential studies a highly significant positive correlation was found between sTNF-RI and sTNF-RII (r = 0.8, P < 0.001) and between both sTNF-R and CD8+ lymphocyte counts (r = 0.6 and 0.92, respectively, P < 0.01-0.001) during the asymptomatic stage of the infection. All these correlations were lost, however, during the symptomatic phase of the disease. These results suggest that: (i) HIV infection is associated with elevation of sTNF-R serum levels; (ii) sTNF-R levels are strongly correlated to CD8+ lymphocytes during the asymptomatic stage of HIV infection.

Original languageEnglish
Pages (from-to)350-355
Number of pages6
JournalClinical and Experimental Immunology
Volume93
Issue number3
DOIs
StatePublished - 1 Jan 1993
Externally publishedYes

Keywords

  • CD8 lymphocytes
  • HIV infection
  • soluble tumour necrosis factor receptors

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