Somatic mutations at the glycophorin A (GPA) locus measured in red cells of Chernobyl liquidators who immigrated to Israel

Vered Y. Wishkerman, Michael R. Quastel, Amos Douvdevani, John R. Goldsmith

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8 Scopus citations

Abstract

Glycophorin A (GPA) assays for human erythrocytes with gene expression loss and duplication phenotypes (NO, NN) were carried out on 15 Chernobyl clean-up workers (liquidators) who immigrated to Israel within the preceding 5 years, 19 local Israeli controls, and 14 Russian (nonliquidator) immigrants. GPA phenotype variants in red blood cells of the 15 liquidators showed values ranging from 1 to 101 events/106 cells, with a mean ± SD of 25.6 ± 7.0. In comparison, the 19 Israeli controls had values ranging from 0 to 13 GPA events per 106 cells, with a mean ± SD of 3.9 ± 0.8. The difference was highly significant (p < 0.001). Another group of 14 volunteer control subjects (nonliquidators) who had emigrated from the former Soviet Union to Israel during the past 5 years showed values ranging from 0.0 to 35.0 events per 106 cells, with a mean ± SD of 6.1 ± 2.7. The difference between this group and the liquidator group was significant at p < 0.01. The results are compatible with past exposure to radiation in the group identified as liquidators.

Original languageEnglish
Pages (from-to)1451-1454
Number of pages4
JournalEnvironmental Health Perspectives
Volume105
Issue numberSUPPL. 6
DOIs
StatePublished - 1 Jan 1997

Keywords

  • Biological dosimetry
  • Biological indicators of exposure
  • Chernobyl
  • Clean-up workers
  • Glycophorin A
  • Liquidators
  • Radiation

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