Some properties of the plasma hGH activity in patients with laron-type dwarfism determined by a radioreceptor assay using human liver tissue

R. Eshet; S. Peleg; Z. Josefsberg; C. Fuchs; R. Arnon; Z. Laron

doi:10.1159/000180106

Some properties of the plasma hGH activity in patients with laron-type dwarfism determined by a radioreceptor assay using human liver tissue

R. Eshet, S. Peleg, Z. Josefsberg, C. Fuchs, R. Arnon, Z. Laron

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-oid male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from I normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.

Original language	English
Pages (from-to)	276-283
Number of pages	8
Journal	Hormone Research in Paediatrics
Volume	22
Issue number	4
DOIs	https://doi.org/10.1159/000180106
State	Published - 1 Jan 1985
Externally published	Yes

Keywords

hGH radioreceptor assay
hGH receptors
Human liver receptors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1159/000180106

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title = "Some properties of the plasma hGH activity in patients with laron-type dwarfism determined by a radioreceptor assay using human liver tissue",

abstract = "A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-oid male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from I normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.",

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author = "R. Eshet and S. Peleg and Z. Josefsberg and C. Fuchs and R. Arnon and Z. Laron",

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AU - Eshet, R.

AU - Peleg, S.

AU - Josefsberg, Z.

AU - Fuchs, C.

AU - Arnon, R.

AU - Laron, Z.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-oid male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from I normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.

AB - A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-oid male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from I normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.

KW - hGH radioreceptor assay

KW - hGH receptors

KW - Human liver receptors

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JO - Hormone Research in Paediatrics

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ER -

Some properties of the plasma hGH activity in patients with laron-type dwarfism determined by a radioreceptor assay using human liver tissue

Abstract

Keywords

ASJC Scopus subject areas

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