Spatial distribution of abnormal EEG activity in Creutzfeldt-Jakob disease

Shmuel Appel, Oren S. Cohen, Joab Chapman, Shlomo Gilat, Hanna Rosenmann, Zeev Nitsan, Esther Kahana, Ilan Blatt

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives: Electroencephalogram (EEG) pattern in Creutzfeldt-Jakob disease (CJD) is characterized by diffuse abnormal activity, although lateralization to one hemisphere has been described in the first stages of the disease. This study aimed to determine whether abnormal EEG activity predominantly occurs in anterior versus posterior brain regions. Methods: As part of a prospective study, the demographics, clinical features and MRI findings of genetic E200K CJD patients were collected. EEG was performed and the recordings reviewed for the typical periodic sharp wave complex (PSWC) and non-specific slow activity. Data were analyzed using the qEEG tool, and the activity in anterior and posterior regions of the brain compared. Results: Eleven genetic E200K CJD patients were included in the study (67% women). The average age was 59.1 ± 8.4 SD years and the average disease duration was 2.4 ± 2.1 months. EEG showed the classic PSWC pattern in 5/11 (45%) of the patients, and slow activity was seen in 9/11 (82%). EEG was normal in 2 patients. PSWC activity was diffuse in 2/5 patients and unilateral in 3/5 patients; slow activity was diffuse in 9 patients. Quantitative analysis of PSWC and slow activity showed no significant difference between anterior and posterior distribution. Conclusion: The abnormal EEG activity in CJD is diffuse with no clear spatial predominance in anterior or posterior brain regions.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalNeurophysiologie Clinique
Issue number3
StatePublished - 1 Jun 2021


  • Creutzfeldt-Jakob disease
  • Distribution
  • E200K
  • Periodic sharp wave complex
  • Quantitative EEG

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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