Specific and label-free femtomolar biomarker detection with an electrostatically formed nanowire biosensor

Gil Shalev, Guy Landman, Iddo Amit, Yossi Rosenwaks, Ilan Levy

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

We report a specific, label-free and real-time detection of femtomolar protein concentrations with a novel type of nanowirebased biosensor. The biosensor is based on an electrostatically formed nanowire, which is conceptually different from a conventional silicon nanowire in its confinement potential, charge carrier distribution, surface states, dopant distribution, moveable channel and geometrical structure. This new biosensor requires standard integrated-circuit processing with relaxed fabrication requirements. The biosensor is composed of an accumulation-type, planar transistor surrounded by four gates, a backgate, front gate and two lateral gates, and it operates in the all-around-depletion mode. Consequently, adjustment of the four gates defines the dimensions and location of the conducting channel. It is shown that lithographically shaped channels of 400nm in width are reduced to effective widths of 25nm upon lateral-gate biasing. Device operation is demonstrated for protein-specific binding, and it is found that sensitive detection signals are recorded once the channel width is comparable with the dimensions of the protein. The device performance is discussed and analyzed with the help of three-dimensional electrostatic simulations.

Original languageEnglish
Article numbere41
JournalNPG Asia Materials
Volume5
Issue number3
DOIs
StatePublished - 1 Mar 2013
Externally publishedYes

Keywords

  • Biosensors
  • Label-free
  • Nanowire

ASJC Scopus subject areas

  • Modeling and Simulation
  • Materials Science (all)
  • Condensed Matter Physics

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