Specificity and cross-reactivity of synthetic peptides derived from a major antigenic site of influenza hemagglutinin

Michal Shapira, Ziva Misulovin, Ruth Arnon

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A synthetic peptide corresponding to sequence 138-164 of influenza hemagglutinin elicited in rabbits antibodies that recognized different parts of the peptide, namely the loop region (139-146) and the rest of the peptide, region 147-164. This was shown both by direct binding and by competitive-inhibition experiments. Individual antisera differed in their specificity. The contribution of the Asp residue at position 144 to the antigenic specificity was shown in various inhibition assays. These data are in accordance with the reported effect of the exchange Gly → Asp on the serological specificity of influenza virus.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalMolecular Immunology
Volume22
Issue number1
DOIs
StatePublished - 1 Jan 1985
Externally publishedYes

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