Spectroscopic investigation of anti-bacterial agents activity

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FTIR spectroscopy has been widely used in recent time as a efficient tool to biomedical investigations. In this study we examined the potential of FTIR microspectroscopy as analytical instrument for early evaluation of anti-bacterial therapy efficiency. For this purpose, the effect of propolis (PE) on the development of bacterial infection in cell culture was examined. PE is a natural honeybee product with a potent antibacterial activity. Our results show early (2h post treatment) unique and significant spectral indicators for successful treatment with PE. Some of these biomarkers demonstrate different trends in gram (-) compared to gram (+) bacteria. It seems that FTIR spectroscopy can be used as an effective analytical tool for an early evaluation of the efficiency of the antibacterial effect of PE and probably other used drugs.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalStudia Universitatis Babes-Bolyai Chemia
Issue number3
StatePublished - 1 Sep 2011


  • Bacteria
  • FTIR microscopy
  • Propolis


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