Spin-lattice relaxation times of imidazole protons and their relevance to NMR studies of proteins

Roderick E. Wasylishen; Jack S. Cohen

doi:10.1038/249847a0

Spin-lattice relaxation times of imidazole protons and their relevance to NMR studies of proteins

Roderick E. Wasylishen, Jack S. Cohen

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Abstract

THE spin lattice relaxation time (T₁) is the exponential time constant for re-equilibration of nuclear spins with their surroundings (the lattice) following resonance excitation, and is consequently related to the correlation time of the nuclei in solution. Thus, the determination of T ₁ values would be of interest in many biological systems. Measurement of the relative motility of different portions of a protein molecule, for example, could shed light on conformational and functional properties.

Original language	English
Pages (from-to)	847-850
Number of pages	4
Journal	Nature
Volume	249
Issue number	5460
DOIs	https://doi.org/10.1038/249847a0
State	Published - 1 Dec 1974
Externally published	Yes

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title = "Spin-lattice relaxation times of imidazole protons and their relevance to NMR studies of proteins",

abstract = "THE spin lattice relaxation time (T1) is the exponential time constant for re-equilibration of nuclear spins with their surroundings (the lattice) following resonance excitation, and is consequently related to the correlation time of the nuclei in solution. Thus, the determination of T 1 values would be of interest in many biological systems. Measurement of the relative motility of different portions of a protein molecule, for example, could shed light on conformational and functional properties.",

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AU - Cohen, Jack S.

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N2 - THE spin lattice relaxation time (T1) is the exponential time constant for re-equilibration of nuclear spins with their surroundings (the lattice) following resonance excitation, and is consequently related to the correlation time of the nuclei in solution. Thus, the determination of T 1 values would be of interest in many biological systems. Measurement of the relative motility of different portions of a protein molecule, for example, could shed light on conformational and functional properties.

AB - THE spin lattice relaxation time (T1) is the exponential time constant for re-equilibration of nuclear spins with their surroundings (the lattice) following resonance excitation, and is consequently related to the correlation time of the nuclei in solution. Thus, the determination of T 1 values would be of interest in many biological systems. Measurement of the relative motility of different portions of a protein molecule, for example, could shed light on conformational and functional properties.

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Spin-lattice relaxation times of imidazole protons and their relevance to NMR studies of proteins

Abstract

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