Spontaneous synchronized bursting in 2D neural networks

Ronen Segev, Eshel Ben-Jacob

Research output: Contribution to journalConference articlepeer-review

17 Scopus citations

Abstract

We present a long-term (hours) measurements of the spontaneous activity of cortical cells 2D neural network placed on multi-electrodes arrays. We compare the histogram of the single neurons inter spike interval and the network inter synchronized bursting events interval. In addition, the effect of Ca concentration on the network activity is being studied. Under 1 mM Ca concentration the network exhibits periodic synchronized bursting. We present a novel feedback regulated integrate & fire model to account of the observations. In the model we include two additional features of dynamical threshold and synapses fatigue.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalPhysica A: Statistical Mechanics and its Applications
Volume302
Issue number1-4
DOIs
StatePublished - 15 Dec 2001
Externally publishedYes
EventInternational Workshop on Frontiers in the Physics of Complex Systems - Ramat-Gan, Israel
Duration: 25 Mar 200128 Mar 2001

Keywords

  • In vitro
  • Integrate & fire model
  • Neural networks
  • Synchronized bursting

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